Sylas Runes explained
There's one set of runes for Sylas on patch 14.21 that is the clear favorite for LoL players and pros alike. The best Sylas rune paths on the position 
Mid are 
Domination as the primary path and 
Resolve as the secondary path with a pick rate of 35%. Besides picking runes on Sylas you should learn how to play Sylas and if you are interested in pro matches take a look on how a pro builds Sylas. If you want to discuss 
Sylas then you should visit the champion subreddit.
Sylas runes from primary path
Domination improves burst damage and assassination tools on Sylas. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Electrocute is the best keystone rune to run on Sylas. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on Sylas are 
Sudden Impact, Eyeball Collection and 
Relentless Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Sylas with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Sylas runes from secondary path
When it comes to your secondary path, most Sylas players prefer to go with Resolve. Resolve empowers the survivability of Sylas and increases the tankiness. On the Resolve path, the best runes for Sylas are Overgrowth and Second Wind.
Overgrowth increases your maximum amount of health. Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion.
FAQ for Sylas Runes
Which is the best keystone rune on Sylas?
The best keystone rune on Sylas is Electrocute. This Sylas runes setup is then referred as Sylas Electrocute.
What runes does Sylas use?
Runes from the paths Domination and Resolve are the most used runes on Sylas. For the exact pick rates of Sylas runes used, you have to study the rune distribution presented.