Sylas Runes explained
There's one set of runes for Sylas on patch 13.1 that is the clear favorite for LoL players and pros alike. The best Sylas rune paths on the position 
Jungle are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 91%. Besides picking runes on Sylas you should learn how to play Sylas and if you are interested in pro matches take a look on how a pro builds Sylas. If you want to discuss 
Sylas then you should visit the champion subreddit.
Sylas runes from primary path
Domination improves burst damage and assassination tools on Sylas. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Dark Harvest is the best keystone rune to run on Sylas. This keystone rune gives you additional damage throughout the match. Other primary runes on Sylas are 
Sudden Impact, 
Eyeball Collection and 
Treasure Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Sylas with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives Sylas additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Sylas will gain an additional 70 gold for the first takedown. Sylas acquires Bounty Hunter Stacks, which Sylas may use to get more takedowns. This rune's power will grow tremendously, and Sylas will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Sylas will get an additional twenty gold.
Sylas runes from secondary path
When it comes to your secondary path, most Sylas players prefer to go with Inspiration. Inspiration opens creative opportunities on Sylas troughout the match. On the Inspiration path, the best runes for Sylas are 
Cosmic Insight and 
Magical Footwear.
Cosmic Insight grants summoner spell and item haste. Magical Footwear allows Sylas to focus on those essential core items without the need to spend the additional 300 gold on boots.
FAQ for Sylas Runes
Which is the best keystone rune on Sylas?
The best keystone rune on Sylas is Dark Harvest. This Sylas runes setup is then referred as Sylas Dark Harvest.
What runes does Sylas use?
Runes from the paths Domination and Inspiration are the most used runes on Sylas. For the exact pick rates of Sylas runes used, you have to study the rune distribution presented.