Maokai Runes explained
There's one set of runes for Maokai on patch 13.21 that is the clear favorite for LoL players and pros alike. The best Maokai rune paths on the position 
Jungle are 
Inspiration as the primary path and 
Domination as the secondary path with a pick rate of 41%. Besides picking runes on Maokai you should learn how to play Maokai and if you are interested in pro matches take a look on how a pro builds Maokai. If you want to discuss 
Maokai then you should visit the champion subreddit.
Maokai runes from primary path
Inspiration opens creative opportunities on Maokai troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
First Strike is the best keystone rune to run on Maokai. Other primary runes on Maokai are 
Magical Footwear, 
Future's Market and 
Cosmic Insight.
Magical Footwear allows Maokai to focus on those essential core items without the need to spend the additional 300 gold on boots. You can enter debt to buy items, which is displayed as negative gold in your inventary. A small lending fee is added onto the amount of gold you owe after leaving the shop. Cosmic Insight grants summoner spell and item haste.
Maokai runes from secondary path
When it comes to your secondary path, most Maokai players prefer to go with Domination. Domination improves burst damage and assassination tools on Maokai. On the Domination path, the best runes for Maokai are Cheap Shot and Treasure Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Maokai. Treasure Hunter is the final rune of the Domination path. This rune gives Maokai additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Maokai will gain an additional 70 gold for the first takedown. Maokai acquires Bounty Hunter Stacks, which Maokai may use to get more takedowns. This rune's power will grow tremendously, and Maokai will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Maokai will get an additional twenty gold.
FAQ for Maokai Runes
Which is the best keystone rune on Maokai?
The best keystone rune on Maokai is First Strike. This Maokai runes setup is then referred as Maokai First Strike.
What runes does Maokai use?
Runes from the paths Inspiration and Domination are the most used runes on Maokai. For the exact pick rates of Maokai runes used, you have to study the rune distribution presented.