Zoe Runes explained
There's one set of runes for Zoe on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Zoe rune paths on the position 
Mid are 
Domination as the primary path and 
Sorcery as the secondary path with a pick rate of 39%. Besides picking runes on Zoe you should learn how to play Zoe and if you are interested in pro matches take a look on how a pro builds Zoe. If you want to discuss 
Zoe then you should visit the champion subreddit.
Zoe runes from primary path
Domination improves burst damage and assassination tools on Zoe. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Electrocute is the best keystone rune to run on Zoe. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on Zoe are 
Taste of Blood, 
Eyeball Collection and 
Relentless Hunter.
Taste of Blood heals Zoe as soon as you damage an opposing champion. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Zoe runes from secondary path
When it comes to your secondary path, most Zoe players prefer to go with Sorcery. Sorcery empoweres abilities of Zoe and increases the available champion resources. On the Sorcery path, the best runes for Zoe are Manaflow Band and Transcendence.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste.
FAQ for Zoe Runes
Which is the best keystone rune on Zoe?
The best keystone rune on Zoe is Electrocute. This Zoe runes setup is then referred as Zoe Electrocute.
What runes does Zoe use?
Runes from the paths Domination and Sorcery are the most used runes on Zoe. For the exact pick rates of Zoe runes used, you have to study the rune distribution presented.