Zoe Runes explained
There's one set of runes for Zoe on patch 15.11 that is the clear favorite for LoL players and pros alike. The best Zoe rune paths on the position 
Mid are 
Inspiration as the primary path and 
Sorcery as the secondary path with a pick rate of 38%. Besides picking runes on Zoe you should learn how to play Zoe and if you are interested in pro matches take a look on how a pro builds Zoe. If you want to discuss 
Zoe then you should visit the champion subreddit.
Zoe runes from primary path
Inspiration opens creative opportunities on Zoe troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Unsealed Spellbook is the best keystone rune to run on Zoe. This keystone rune allows Zoe to create a one-time use summoner spell. The new summoner spell replaces one of their current summoner spells and remains available until it is used or replaced. Unsealed Spellbook has some unique rules in that a particular summoner spell cannot be selected again until three other unique spells have been taken. LoL pro players will often use Unsealed Spellbook to aid them in their current or upcoming situation. Are you about to fight the last dragon for a soul buff? Due to Unsealed Spellbook, Zoe can choose 
Smite to help their jungler secure the dragon for the team. There are numberless circumstances where a particular summoner spell can turn the game on its head, and that's where Unsealed Spellbook shines the most. Other primary runes on Zoe are 
Magical Footwear, 
Biscuit Delivery and 
Cosmic Insight.
Magical Footwear allows Zoe to focus on those essential core items without the need to spend the additional 300 gold on boots. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
Zoe runes from secondary path
When it comes to your secondary path, most Zoe players prefer to go with Sorcery. Sorcery empoweres abilities of Zoe and increases the available champion resources. On the Sorcery path, the best runes for Zoe are 
Transcendence and 
Nimbus Cloak.
Transcendence for some more Ability Haste. Nimbus Cloak, which grants movement speed upon using a summoner spell, works amazingly well with junglers in particular as they take the shortest cooldown summoner spell, Smite.
FAQ for Zoe Runes
Which is the best keystone rune on Zoe?
The best keystone rune on Zoe is Unsealed Spellbook. This Zoe runes setup is then referred as Zoe Unsealed Spellbook.
What runes does Zoe use?
Runes from the paths Inspiration and Sorcery are the most used runes on Zoe. For the exact pick rates of Zoe runes used, you have to study the rune distribution presented.