Zoe Runes explained
There's one set of runes for Zoe on patch 15.12 that is the clear favorite for LoL players and pros alike. The best Zoe rune paths on the position 
Mid are 
Domination as the primary path and 
Sorcery as the secondary path with a pick rate of 38%. Besides picking runes on Zoe you should learn how to play Zoe and if you are interested in pro matches take a look on how a pro builds Zoe. If you want to discuss 
Zoe then you should visit the champion subreddit.
Zoe runes from primary path
Domination improves burst damage and assassination tools on Zoe. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Unsealed Spellbook is the best keystone rune to run on Zoe. This keystone rune allows Zoe to create a one-time use summoner spell. The new summoner spell replaces one of their current summoner spells and remains available until it is used or replaced. Unsealed Spellbook has some unique rules in that a particular summoner spell cannot be selected again until three other unique spells have been taken. LoL pro players will often use Unsealed Spellbook to aid them in their current or upcoming situation. Are you about to fight the last dragon for a soul buff? Due to Unsealed Spellbook, Zoe can choose 
Smite to help their jungler secure the dragon for the team. There are numberless circumstances where a particular summoner spell can turn the game on its head, and that's where Unsealed Spellbook shines the most. Other primary runes on Zoe are 
Taste of Blood, 
Grisly Mementos and 
Relentless Hunter.
Taste of Blood heals Zoe as soon as you damage an opposing champion. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Zoe runes from secondary path
When it comes to your secondary path, most Zoe players prefer to go with Sorcery. Sorcery empoweres abilities of Zoe and increases the available champion resources. On the Sorcery path, the best runes for Zoe are 
Scorch and 
Nimbus Cloak.
Scorch increases your control in the early game. Nimbus Cloak, which grants movement speed upon using a summoner spell, works amazingly well with junglers in particular as they take the shortest cooldown summoner spell, Smite.
FAQ for Zoe Runes
Which is the best keystone rune on Zoe?
The best keystone rune on Zoe is Unsealed Spellbook. This Zoe runes setup is then referred as Zoe Unsealed Spellbook.
What runes does Zoe use?
Runes from the paths Domination and Sorcery are the most used runes on Zoe. For the exact pick rates of Zoe runes used, you have to study the rune distribution presented.