Zyra Runes explained
There's one set of runes for Zyra on patch 14.12 that is the clear favorite for LoL players and pros alike. The best Zyra rune paths on the position 
Jungle are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 37%. Besides picking runes on Zyra you should learn how to play Zyra and if you are interested in pro matches take a look on how a pro builds Zyra. If you want to discuss 
Zyra then you should visit the champion subreddit.
Zyra runes from primary path
Domination improves burst damage and assassination tools on Zyra. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Arcane Comet is the best keystone rune to run on Zyra. This keystone rune adds more damage to your abilities and increases your power in the laning phase. Other primary runes on Zyra are 
Cheap Shot, Eyeball Collection and 
Treasure Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Zyra. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives Zyra additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Zyra will gain an additional 70 gold for the first takedown. Zyra acquires Bounty Hunter Stacks, which Zyra may use to get more takedowns. This rune's power will grow tremendously, and Zyra will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Zyra will get an additional twenty gold.
Zyra runes from secondary path
When it comes to your secondary path, most Zyra players prefer to go with Inspiration. Inspiration opens creative opportunities on Zyra troughout the match. On the Inspiration path, the best runes for Zyra are Cosmic Insight and Cash Back.
Cosmic Insight grants summoner spell and item haste. You can enter debt to buy items, which is displayed as negative gold in your inventary. A small lending fee is added onto the amount of gold you owe after leaving the shop.
FAQ for Zyra Runes
Which is the best keystone rune on Zyra?
The best keystone rune on Zyra is Arcane Comet. This Zyra runes setup is then referred as Zyra Arcane Comet.
What runes does Zyra use?
Runes from the paths Domination and Inspiration are the most used runes on Zyra. For the exact pick rates of Zyra runes used, you have to study the rune distribution presented.