Ziggs Runes explained
There's one set of runes for Ziggs on patch 15.12 that is the clear favorite for LoL players and pros alike. The best Ziggs rune paths on the position 
Mid are 
Sorcery as the primary path and 
Precision as the secondary path with a pick rate of 58%. Besides picking runes on Ziggs you should learn how to play Ziggs and if you are interested in pro matches take a look on how a pro builds Ziggs. If you want to discuss 
Ziggs then you should visit the champion subreddit.
Ziggs runes from primary path
Sorcery empoweres abilities of Ziggs and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Arcane Comet is the best keystone rune to run on Ziggs. This keystone rune adds more damage to your abilities and increases your power in the laning phase. Other primary runes on Ziggs are 
Manaflow Band, 
Transcendence and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste. Scorch increases your control in the early game.
Ziggs runes from secondary path
When it comes to your secondary path, most Ziggs players prefer to go with Precision. Precision improves attack and sustained damage on Ziggs troughout the match. On the Precision path, the best runes for Ziggs are 
Presence of Mind and 
Coup de Grace.
Presence of Mind helps Ziggs with the mana problems by restoring missing mana, if a champion is killed. Ziggs deals with Coup de Grace more damage to targets with low health.
FAQ for Ziggs Runes
Which is the best keystone rune on Ziggs?
The best keystone rune on Ziggs is Arcane Comet. This Ziggs runes setup is then referred as Ziggs Arcane Comet.
What runes does Ziggs use?
Runes from the paths Sorcery and Precision are the most used runes on Ziggs. For the exact pick rates of Ziggs runes used, you have to study the rune distribution presented.