Ziggs Runes explained
There's one set of runes for Ziggs on patch
11.20
that is the clear favorite for LoL players and pros alike. The best Ziggs Runes on the position 
Adc are Sorcery as the primary path and
Inspiration as the secondary path with a pick rate of 99%. Besides runes you should take a look on Ziggs Build and if you are interested in pro matches take a look at Ziggs Probuilds. If you want to discuss
Ziggs then you should visit the champion subreddit.
Primary path on Ziggs
Sorcery empoweres abilities of Ziggs and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Arcane Comet is the best keystone rune to run on
Ziggs. This keystone rune adds more damage to your abilities and increases your power in the laning phase. This is usually followed up by taking
Manaflow Band,
Transcendence and
Gathering Storm.
This is usually followed up by taking
Manaflow Band for additional mana and mana regenaration.
Transcendence for some more Ability Haste.
Gathering Storm increases your late game power.
Secondary path on Ziggs
When it comes to your secondary path, most
Ziggs players prefer to go with
Inspiration.
Inspiration opens creative opportunities on Ziggs troughout the match. On the
Inspiration path, the best runes for Ziggs are
Biscuit Delivery and
Cosmic Insight.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
Cosmic Insight grants summoner spell and item haste.
FAQ for Ziggs Runes
Which is the best keystone rune on Ziggs?
The best keystone rune on Ziggs is
Arcane Comet.