Zeri Runes explained
There's one set of runes for Zeri on patch 14.9 that is the clear favorite for LoL players and pros alike. The best Zeri rune paths on the position 
Adc are 
Precision as the primary path and 
Resolve as the secondary path with a pick rate of 71%. Besides picking runes on Zeri you should learn how to play Zeri and if you are interested in pro matches take a look on how a pro builds Zeri. If you want to discuss 
Zeri then you should visit the champion subreddit.
Zeri runes from primary path
Precision improves attack and sustained damage on Zeri troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Lethal Tempo is the best keystone rune to run on Zeri. This keystone rune gives Zeri a great head start in team fights and allows to put out more damage in that time window. Other primary runes on Zeri are 
Overheal, 
Legend: Bloodline and 
Last Stand.
Overheal converts healing in excess of maximum health of Zeri into a shield, which provides additional safty and tankiness. Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match. With Last Stand you deal more damage while you are at low health.
Zeri runes from secondary path
When it comes to your secondary path, most Zeri players prefer to go with Resolve. Resolve empowers the survivability of Zeri and increases the tankiness. On the Resolve path, the best runes for Zeri are Overgrowth and Conditioning.
Overgrowth increases your maximum amount of health. Conditioning powers up Zeri tankiness after the laning phase.
FAQ for Zeri Runes
Which is the best keystone rune on Zeri?
The best keystone rune on Zeri is Lethal Tempo. This Zeri runes setup is then referred as Zeri Lethal Tempo.
What runes does Zeri use?
Runes from the paths Precision and Resolve are the most used runes on Zeri. For the exact pick rates of Zeri runes used, you have to study the rune distribution presented.