Yorick Runes explained
There's one set of runes for Yorick on patch 14.22 that is the clear favorite for LoL players and pros alike. The best Yorick rune paths on the position 
Top are 
Resolve as the primary path and 
Precision as the secondary path with a pick rate of 70%. Besides picking runes on Yorick you should learn how to play Yorick and if you are interested in pro matches take a look on how a pro builds Yorick. If you want to discuss 
Yorick then you should visit the champion subreddit.
Yorick runes from primary path
Resolve empowers the survivability of Yorick and increases the tankiness. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Conqueror is the best keystone rune to run on Yorick. This keystone rune provides additional power in the later stages of a game. As soon as Conqueror is fully charged, Yorick deals additional damage and gains life steal. Other primary runes on Yorick are 
Demolish, 
Second Wind and 
Overgrowth.
Demolish increases your pressure on the enemy turrets. This rune will help you to punish bad roams or backtimings of your lane opponent. Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion. Overgrowth increases your maximum amount of health.
Yorick runes from secondary path
When it comes to your secondary path, most Yorick players prefer to go with Precision. Precision improves attack and sustained damage on Yorick troughout the match. On the Precision path, the best runes for Yorick are 
Presence of Mind and 
Legend: Bloodline.
Presence of Mind helps Yorick with the mana problems by restoring missing mana, if a champion is killed. Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match.
FAQ for Yorick Runes
Which is the best keystone rune on Yorick?
The best keystone rune on Yorick is Conqueror. This Yorick runes setup is then referred as Yorick Conqueror.
What runes does Yorick use?
Runes from the paths Resolve and Precision are the most used runes on Yorick. For the exact pick rates of Yorick runes used, you have to study the rune distribution presented.