Xayah Runes explained
There's one set of runes for Xayah on patch 14.23 that is the clear favorite for LoL players and pros alike. The best Xayah rune paths on the position 
Adc are 
Precision as the primary path and 
Inspiration as the secondary path with a pick rate of 82%. Besides picking runes on Xayah you should learn how to play Xayah and if you are interested in pro matches take a look on how a pro builds Xayah. If you want to discuss 
Xayah then you should visit the champion subreddit.
Xayah runes from primary path
Precision improves attack and sustained damage on Xayah troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Lethal Tempo is the best keystone rune to run on Xayah. This keystone rune gives Xayah a great head start in team fights and allows to put out more damage in that time window. Other primary runes on Xayah are 
Presence of Mind, 
Legend: Bloodline and 
Cut Down.
Presence of Mind helps Xayah with the mana problems by restoring missing mana, if a champion is killed. Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match. If the enemy team consists of multiple tanks, then the rune Cut Down is the best choice.
Xayah runes from secondary path
When it comes to your secondary path, most Xayah players prefer to go with Inspiration. Inspiration opens creative opportunities on Xayah troughout the match. On the Inspiration path, the best runes for Xayah are 
Cosmic Insight and 
Biscuit Delivery.
Cosmic Insight grants summoner spell and item haste. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
FAQ for Xayah Runes
Which is the best keystone rune on Xayah?
The best keystone rune on Xayah is Lethal Tempo. This Xayah runes setup is then referred as Xayah Lethal Tempo.
What runes does Xayah use?
Runes from the paths Precision and Inspiration are the most used runes on Xayah. For the exact pick rates of Xayah runes used, you have to study the rune distribution presented.