Xayah Runes explained
There's one set of runes for Xayah on patch
12.12
that is the clear favorite for LoL players and pros alike. The best Xayah Runes on the position 
Adc are Precision as the primary path and
Inspiration as the secondary path with a pick rate of 45%. Besides runes you should take a look on Xayah Build and if you are interested in pro matches take a look at Xayah Probuilds.
Primary runes path on Xayah
Precision improves attack and sustained damage on Xayah troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Lethal Tempo is the best keystone rune to run on
Xayah. This keystone rune gives Xayah a great head start in team fights and allows to put out more damage in that time window. Other primary runes on Xayah are
Presence of Mind,
Legend: Bloodline and
Coup de Grace.
Presence of Mind helps Xayah with the mana problems by restoring missing mana, if a champion is killed.
Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match. Xayah deals with
Coup de Grace more damage to targets with low health.
Secondary runes path on Xayah
When it comes to your secondary path, most
Xayah players prefer to go with
Inspiration.
Inspiration opens creative opportunities on Xayah troughout the match. On the
Inspiration path, the best runes for Xayah are
Biscuit Delivery and
Magical Footwear.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
Magical Footwear allows Xayah to focus on those essential core items without the need to spend the additional 300 gold on boots.
FAQ for Xayah Runes
Which is the best keystone rune on Xayah?
The best keystone rune on Xayah is
Lethal Tempo. This Xayah runes setup is then referred as Xayah Lethal Tempo.