Vladimir Runes explained
There's one set of runes for Vladimir on patch 14.19 that is the clear favorite for LoL players and pros alike. The best Vladimir rune paths on the position 
Top are 
Resolve as the primary path and 
Sorcery as the secondary path with a pick rate of 50%. Besides picking runes on Vladimir you should learn how to play Vladimir and if you are interested in pro matches take a look on how a pro builds Vladimir. If you want to discuss 
Vladimir then you should visit the champion subreddit.
Vladimir runes from primary path
Resolve empowers the survivability of Vladimir and increases the tankiness. Most of high elo players – and our LoL pros in the the major regions – have agreed that Grasp of the Undying is the best keystone rune to run on Vladimir. This keystone rune gives Vladimir alot of sustain and helps to force your opposing champion out of the lane. Other primary runes on Vladimir are Demolish, Conditioning and Overgrowth.
Demolish increases your pressure on the enemy turrets. This rune will help you to punish bad roams or backtimings of your lane opponent. Conditioning powers up Vladimir tankiness after the laning phase. Overgrowth increases your maximum amount of health.
Vladimir runes from secondary path
When it comes to your secondary path, most Vladimir players prefer to go with Sorcery. Sorcery empoweres abilities of Vladimir and increases the available champion resources. On the Sorcery path, the best runes for Vladimir are 
Transcendence and 
Gathering Storm.
Transcendence for some more Ability Haste. Gathering Storm increases your late game power.
FAQ for Vladimir Runes
Which is the best keystone rune on Vladimir?
The best keystone rune on Vladimir is Grasp of the Undying. This Vladimir runes setup is then referred as Vladimir Grasp of the Undying.
What runes does Vladimir use?
Runes from the paths Resolve and Sorcery are the most used runes on Vladimir. For the exact pick rates of Vladimir runes used, you have to study the rune distribution presented.