Vel'Koz Runes explained
There's one set of runes for Vel'Koz on patch 14.10 that is the clear favorite for LoL players and pros alike. The best Vel'Koz rune paths on the position 
Mid are 
Sorcery as the primary path and 
Inspiration as the secondary path with a pick rate of 44%. Besides picking runes on Vel'Koz you should learn how to play Vel'Koz and if you are interested in pro matches take a look on how a pro builds Vel'Koz. If you want to discuss 
Vel'Koz then you should visit the champion subreddit.
Vel'Koz runes from primary path
Sorcery empoweres abilities of Vel'Koz and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that First Strike is the best keystone rune to run on Vel'Koz. Other primary runes on Vel'Koz are 
Manaflow Band, 
Celerity and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Celerity boosts all movement speed bonuses to Vel'Koz. Scorch increases your control in the early game.
Vel'Koz runes from secondary path
When it comes to your secondary path, most Vel'Koz players prefer to go with Inspiration. Inspiration opens creative opportunities on Vel'Koz troughout the match. On the Inspiration path, the best runes for Velkoz are Cosmic Insight and Cash Back.
Cosmic Insight grants summoner spell and item haste. You can enter debt to buy items, which is displayed as negative gold in your inventary. A small lending fee is added onto the amount of gold you owe after leaving the shop.
FAQ for Vel'Koz Runes
Which is the best keystone rune on Vel'Koz?
The best keystone rune on Vel'Koz is First Strike. This Vel'Koz runes setup is then referred as Vel'Koz First Strike.
What runes does Vel'Koz use?
Runes from the paths Sorcery and Inspiration are the most used runes on Vel'Koz. For the exact pick rates of Vel'Koz runes used, you have to study the rune distribution presented.