Vayne Runes explained
There's one set of runes for Vayne on patch 15.14 that is the clear favorite for LoL players and pros alike. The best Vayne rune paths on the position 
Adc are 
Precision as the primary path and 
Sorcery as the secondary path with a pick rate of 41%. Besides picking runes on Vayne you should learn how to play Vayne and if you are interested in pro matches take a look on how a pro builds Vayne. If you want to discuss 
Vayne then you should visit the champion subreddit.
Vayne runes from primary path
Precision improves attack and sustained damage on Vayne troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Lethal Tempo is the best keystone rune to run on Vayne. This keystone rune gives Vayne a great head start in team fights and allows to put out more damage in that time window. Other primary runes on Vayne are 
Triumph, 
Legend: Bloodline and 
Cut Down.
Triumph restores on Vayne a part of missing health and award bonus gold, if a champion is killed. Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match. If the enemy team consists of multiple tanks, then the rune Cut Down is the best choice.
Vayne runes from secondary path
When it comes to your secondary path, most Vayne players prefer to go with Sorcery. Sorcery empoweres abilities of Vayne and increases the available champion resources. On the Sorcery path, the best runes for Vayne are 
Celerity and 
Nimbus Cloak.
Celerity boosts all movement speed bonuses to Vayne. Nimbus Cloak, which grants movement speed upon using a summoner spell, works amazingly well with junglers in particular as they take the shortest cooldown summoner spell, 
Smite.
FAQ for Vayne Runes
Which is the best keystone rune on Vayne?
The best keystone rune on Vayne is Lethal Tempo. This Vayne runes setup is then referred as Vayne Lethal Tempo.
What runes does Vayne use?
Runes from the paths Precision and Sorcery are the most used runes on Vayne. For the exact pick rates of Vayne runes used, you have to study the rune distribution presented.