Varus Runes explained
There's one set of runes for Varus on patch 14.9 that is the clear favorite for LoL players and pros alike. The best Varus rune paths on the position 
Adc are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 55%. Besides picking runes on Varus you should learn how to play Varus and if you are interested in pro matches take a look on how a pro builds Varus. If you want to discuss 
Varus then you should visit the champion subreddit.
Varus runes from primary path
Domination improves burst damage and assassination tools on Varus. Most of high elo players – and our LoL pros in the the major regions – have agreed that Hail of Blades is the best keystone rune to run on Varus. This keystone rune helps you to win short damage trades in your lane by increasing your attackspeed at the beginning of a fight. Other primary runes on Varus are Taste of Blood, Eyeball Collection and Treasure Hunter.
Taste of Blood heals Varus as soon as you damage an opposing champion. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives Varus additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Varus will gain an additional 70 gold for the first takedown. Varus acquires Bounty Hunter Stacks, which Varus may use to get more takedowns. This rune's power will grow tremendously, and Varus will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Varus will get an additional twenty gold.
Varus runes from secondary path
When it comes to your secondary path, most Varus players prefer to go with Inspiration. Inspiration opens creative opportunities on Varus troughout the match. On the Inspiration path, the best runes for Varus are 
Biscuit Delivery and 
Cosmic Insight.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
FAQ for Varus Runes
Which is the best keystone rune on Varus?
The best keystone rune on Varus is Hail of Blades. This Varus runes setup is then referred as Varus Hail of Blades.
What runes does Varus use?
Runes from the paths Domination and Inspiration are the most used runes on Varus. For the exact pick rates of Varus runes used, you have to study the rune distribution presented.