Teemo Runes explained
There's one set of runes for Teemo on patch 14.22 that is the clear favorite for LoL players and pros alike. The best Teemo rune paths on the position 
Jungle are 
Domination as the primary path and 
Sorcery as the secondary path with a pick rate of 51%. Besides picking runes on Teemo you should learn how to play Teemo and if you are interested in pro matches take a look on how a pro builds Teemo. If you want to discuss 
Teemo then you should visit the champion subreddit.
Teemo runes from primary path
Domination improves burst damage and assassination tools on Teemo. Most of high elo players – and our LoL pros in the the major regions – have agreed that Dark Harvest is the best keystone rune to run on Teemo. This keystone rune gives you additional damage throughout the match. Other primary runes on Teemo are Cheap Shot, Eyeball Collection and Ultimate Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Teemo. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Ultimate Hunter scales up Teemo ultimate haste on every unique champion takedown.
Teemo runes from secondary path
When it comes to your secondary path, most Teemo players prefer to go with Sorcery. Sorcery empoweres abilities of Teemo and increases the available champion resources. On the Sorcery path, the best runes for Teemo are 
Gathering Storm and 
Absolute Focus.
Gathering Storm increases your late game power. Absolute Focus grants additional damage while Teemo is alomst full health.
FAQ for Teemo Runes
Which is the best keystone rune on Teemo?
The best keystone rune on Teemo is Dark Harvest. This Teemo runes setup is then referred as Teemo Dark Harvest.
What runes does Teemo use?
Runes from the paths Domination and Sorcery are the most used runes on Teemo. For the exact pick rates of Teemo runes used, you have to study the rune distribution presented.