Sejuani Runes explained
There's one set of runes for Sejuani on patch
12.9
that is the clear favorite for LoL players and pros alike. The best Sejuani Runes on the position 
Top are Resolve as the primary path and
Inspiration as the secondary path with a pick rate of 83%. Besides runes you should take a look on Sejuani Build and if you are interested in pro matches take a look at Sejuani Probuilds. If you want to discuss
Sejuani then you should visit the champion subreddit.
Primary runes path on Sejuani
Resolve empowers the survivability of Sejuani and increases the tankiness. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Grasp of the Undying is the best keystone rune to run on
Sejuani. This keystone rune gives Sejuani alot of sustain and helps to force your opposing champion out of the lane. Other primary runes on Sejuani are
Demolish,
Second Wind and
Overgrowth.
Demolish increases your pressure on the enemy turrets. This rune will help you to punish bad roams or backtimings of your lane opponent.
Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion.
Overgrowth increases your maximum amount of health.
Secondary runes path on Sejuani
When it comes to your secondary path, most
Sejuani players prefer to go with
Inspiration.
Inspiration opens creative opportunities on Sejuani troughout the match. On the
Inspiration path, the best runes for Sejuani are
Biscuit Delivery and
Cosmic Insight.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
Cosmic Insight grants summoner spell and item haste.
FAQ for Sejuani Runes
Which is the best keystone rune on Sejuani?
The best keystone rune on Sejuani is
Grasp of the Undying. This Sejuani runes setup is then referred as Sejuani Grasp of the Undying.