Samira Runes explained
There's one set of runes for Samira on patch 14.23 that is the clear favorite for LoL players and pros alike. The best Samira rune paths on the position 
Adc are 
Precision as the primary path and 
Domination as the secondary path with a pick rate of 75%. Besides picking runes on Samira you should learn how to play Samira and if you are interested in pro matches take a look on how a pro builds Samira. If you want to discuss 
Samira then you should visit the champion subreddit.
Samira runes from primary path
Precision improves attack and sustained damage on Samira troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Conqueror is the best keystone rune to run on Samira. This keystone rune provides additional power in the later stages of a game. As soon as Conqueror is fully charged, Samira deals additional damage and gains life steal. Other primary runes on Samira are 
Triumph, 
Legend: Bloodline and 
Last Stand.
Triumph restores on Samira a part of missing health and award bonus gold, if a champion is killed. Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match. With Last Stand you deal more damage while you are at low health.
Samira runes from secondary path
When it comes to your secondary path, most Samira players prefer to go with Domination. Domination improves burst damage and assassination tools on Samira. On the Domination path, the best runes for Samira are 
Treasure Hunter and 
Sudden Impact.
Treasure Hunter is the final rune of the Domination path. This rune gives Samira additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Samira will gain an additional 70 gold for the first takedown. Samira acquires Bounty Hunter Stacks, which Samira may use to get more takedowns. This rune's power will grow tremendously, and Samira will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Samira will get an additional twenty gold. Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Samira with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier.
FAQ for Samira Runes
Which is the best keystone rune on Samira?
The best keystone rune on Samira is Conqueror. This Samira runes setup is then referred as Samira Conqueror.
What runes does Samira use?
Runes from the paths Precision and Domination are the most used runes on Samira. For the exact pick rates of Samira runes used, you have to study the rune distribution presented.