Ryze Runes explained
There's one set of runes for Ryze on patch 14.23 that is the clear favorite for LoL players and pros alike. The best Ryze rune paths on the position 
Mid are 
Sorcery as the primary path and 
Resolve as the secondary path with a pick rate of 40%. Besides picking runes on Ryze you should learn how to play Ryze and if you are interested in pro matches take a look on how a pro builds Ryze. If you want to discuss 
Ryze then you should visit the champion subreddit.
Ryze runes from primary path
Sorcery empoweres abilities of Ryze and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Phase Rush is the best keystone rune to run on Ryze. Phase Rush offers more flexibility and options to betake oneself in and out of danger, which can be helpful since that's essentially the main playstyle of Ryze. Other primary runes on Ryze are 
Manaflow Band, 
Transcendence and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste. Scorch increases your control in the early game.
Ryze runes from secondary path
When it comes to your secondary path, most Ryze players prefer to go with Resolve. Resolve empowers the survivability of Ryze and increases the tankiness. On the Resolve path, the best runes for Ryze are Overgrowth and Bone Plating.
Overgrowth increases your maximum amount of health. Bone Plating make Ryze overall tankier, by decreasing the amount of poke damage in the early game.
FAQ for Ryze Runes
Which is the best keystone rune on Ryze?
The best keystone rune on Ryze is Phase Rush. This Ryze runes setup is then referred as Ryze Phase Rush.
What runes does Ryze use?
Runes from the paths Sorcery and Resolve are the most used runes on Ryze. For the exact pick rates of Ryze runes used, you have to study the rune distribution presented.