Rengar Runes explained
There's one set of runes for Rengar on patch 13.21 that is the clear favorite for LoL players and pros alike. The best Rengar rune paths on the position 
Jungle are 
Inspiration as the primary path and 
Domination as the secondary path with a pick rate of 56%. Besides picking runes on Rengar you should learn how to play Rengar and if you are interested in pro matches take a look on how a pro builds Rengar. If you want to discuss 
Rengar then you should visit the champion subreddit.
Rengar runes from primary path
Inspiration opens creative opportunities on Rengar troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
First Strike is the best keystone rune to run on Rengar. Other primary runes on Rengar are 
Magical Footwear, 
Future's Market and 
Cosmic Insight.
Magical Footwear allows Rengar to focus on those essential core items without the need to spend the additional 300 gold on boots. You can enter debt to buy items, which is displayed as negative gold in your inventary. A small lending fee is added onto the amount of gold you owe after leaving the shop. Cosmic Insight grants summoner spell and item haste.
Rengar runes from secondary path
When it comes to your secondary path, most Rengar players prefer to go with Domination. Domination improves burst damage and assassination tools on Rengar. On the Domination path, the best runes for Rengar are 
Sudden Impact and 
Treasure Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Rengar with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Treasure Hunter is the final rune of the Domination path. This rune gives Rengar additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Rengar will gain an additional 70 gold for the first takedown. Rengar acquires Bounty Hunter Stacks, which Rengar may use to get more takedowns. This rune's power will grow tremendously, and Rengar will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Rengar will get an additional twenty gold.
FAQ for Rengar Runes
Which is the best keystone rune on Rengar?
The best keystone rune on Rengar is First Strike. This Rengar runes setup is then referred as Rengar First Strike.
What runes does Rengar use?
Runes from the paths Inspiration and Domination are the most used runes on Rengar. For the exact pick rates of Rengar runes used, you have to study the rune distribution presented.