Quinn Runes explained
There's one set of runes for Quinn on patch
11.15
that is the clear favorite for LoL players and pros alike. The best Quinn Runes on the position 
Top are Precision as the primary path and
Domination as the secondary path with a pick rate of 64%. Besides runes you should take a look on Quinn Build and if you are interested in pro matches take a look at Quinn Probuilds. If you want to discuss
Quinn then you should visit the champion subreddit.
Primary path on Quinn
Precision improves attack and sustained damage on Quinn troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Press the Attack is the best keystone rune to run on
Quinn. Quinn has a very easy time activating this rune with basic attacks which synergises well with
Press the Attack’s damage increase once activated. This is usually followed up by taking
Overheal,
Legend: Alacrity and
Cut Down.
Overheal converts healing in excess of maximum health of Quinn into a shield, which provides additional safty and tankiness.
Legend: Alacrity grants additional attack speed to Quinn. If the enemy team consists of multiple tanks, then the rune
Cut Down is the best choice.
Secondary path on Quinn
When it comes to your secondary path, most
Quinn players prefer to go with
Domination.
Domination improves burst damage and assassination tools on Quinn. On the
Domination path, the best runes for Quinn are
Taste of Blood and
Ravenous Hunter.
Taste of Blood heals Quinn as soon as you damage an opposing champion.
Ravenous Hunter is the final rune of the
Domination path. This rune gives some survivability during short fights and damage trades during the laning phase. The additional health is nothing to scoff at and can mean the difference between winning or losing a battle.