Pyke Runes explained
There's one set of runes for Pyke on patch 15.12 that is the clear favorite for LoL players and pros alike. The best Pyke rune paths on the position 
Support are 
Domination as the primary path and 
Resolve as the secondary path with a pick rate of 59%. Besides picking runes on Pyke you should learn how to play Pyke and if you are interested in pro matches take a look on how a pro builds Pyke. If you want to discuss 
Pyke then you should visit the champion subreddit.
Pyke runes from primary path
Domination improves burst damage and assassination tools on Pyke. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Hail of Blades is the best keystone rune to run on Pyke. This keystone rune helps you to win short damage trades in your lane by increasing your attackspeed at the beginning of a fight. Other primary runes on Pyke are 
Cheap Shot, 
Deep Ward and 
Relentless Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Pyke. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Pyke runes from secondary path
When it comes to your secondary path, most Pyke players prefer to go with Resolve. Resolve empowers the survivability of Pyke and increases the tankiness. On the Resolve path, the best runes for Pyke are 
Unflinching and 
Bone Plating.
Unflinching inceases Pyke tenacity based on your missing health. Bone Plating make Pyke overall tankier, by decreasing the amount of poke damage in the early game.
FAQ for Pyke Runes
Which is the best keystone rune on Pyke?
The best keystone rune on Pyke is Hail of Blades. This Pyke runes setup is then referred as Pyke Hail of Blades.
What runes does Pyke use?
Runes from the paths Domination and Resolve are the most used runes on Pyke. For the exact pick rates of Pyke runes used, you have to study the rune distribution presented.