Pyke Runes explained
There's one set of runes for Pyke on patch
11.8
that is the clear favorite for LoL players and pros alike. The best Pyke Runes on the position 
Support are Domination as the primary path and
Inspiration as the secondary path with a pick rate of 34%. Besides runes you should take a look on Pyke Build and if you are interested in pro matches take a look at Pyke Probuilds. If you want to discuss
Pyke then you should visit the champion subreddit.
Primary path on Pyke
Domination improves burst damage and assassination tools on Pyke. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Hail of Blades is the best keystone rune to run on
Pyke. This keystone rune helps you to win short damage trades in your lane by increasing your attackspeed at the beginning of a fight. This is usually followed up by taking
Cheap Shot,
Zombie Ward and
Ultimate Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Pyke.
Zombie Ward helps you to expand your vision on the map. Vision is very crucial in LoL and helps you to avoid unnecessary deaths.
Ultimate Hunter scales up Pyke ultimate haste on every unique champion takedown.
Secondary path on Pyke
When it comes to your secondary path, most
Pyke players prefer to go with
Inspiration.
Inspiration opens creative opportunities on Pyke troughout the match. On the
Inspiration path, the best runes for Pyke are
Biscuit Delivery and
Cosmic Insight.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
Cosmic Insight grants summoner spell and item haste.