Poppy Runes explained
There's one set of runes for Poppy on patch 14.12 that is the clear favorite for LoL players and pros alike. The best Poppy rune paths on the position 
Support are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 71%. Besides picking runes on Poppy you should learn how to play Poppy and if you are interested in pro matches take a look on how a pro builds Poppy. If you want to discuss 
Poppy then you should visit the champion subreddit.
Poppy runes from primary path
Domination improves burst damage and assassination tools on Poppy. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Hail of Blades is the best keystone rune to run on Poppy. This keystone rune helps you to win short damage trades in your lane by increasing your attackspeed at the beginning of a fight. Other primary runes on Poppy are 
Sudden Impact, 
Zombie Ward and 
Relentless Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Poppy with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Zombie Ward helps you to expand your vision on the map. Vision is very
crucial in LoL and helps you to avoid unnecessary deaths. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Poppy runes from secondary path
When it comes to your secondary path, most Poppy players prefer to go with Inspiration. Inspiration opens creative opportunities on Poppy troughout the match. On the Inspiration path, the best runes for Poppy are 
Hextech Flashtraption and 
Cosmic Insight.
Having an extra way to decrease the distance with the Hextech Flashtraption will make an engage much easier to pull off. Cosmic Insight grants summoner spell and item haste.
FAQ for Poppy Runes
Which is the best keystone rune on Poppy?
The best keystone rune on Poppy is Hail of Blades. This Poppy runes setup is then referred as Poppy Hail of Blades.
What runes does Poppy use?
Runes from the paths Domination and Inspiration are the most used runes on Poppy. For the exact pick rates of Poppy runes used, you have to study the rune distribution presented.