Pantheon Runes explained
There's one set of runes for Pantheon on patch
12.10
that is the clear favorite for LoL players and pros alike. The best Pantheon Runes on the position 
Support are Precision as the primary path and
Domination as the secondary path with a pick rate of 75%. Besides runes you should take a look on Pantheon Build and if you are interested in pro matches take a look at Pantheon Probuilds. If you want to discuss
Pantheon then you should visit the champion subreddit.
Primary runes path on Pantheon
Precision improves attack and sustained damage on Pantheon troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Conqueror is the best keystone rune to run on
Pantheon. This keystone rune provides additional power in the later stages of a game. As soon as
Conqueror is fully charged, Pantheon deals additional damage and gains life steal. Other primary runes on Pantheon are
Presence of Mind,
Legend: Tenacity and
Coup de Grace.
Presence of Mind helps Pantheon with the mana problems by restoring missing mana, if a champion is killed. Pantheon gains extra Tenacity with every additional stage of
Legend: Tenacity. Pantheon deals with
Coup de Grace more damage to targets with low health.
Secondary runes path on Pantheon
When it comes to your secondary path, most
Pantheon players prefer to go with
Domination.
Domination improves burst damage and assassination tools on Pantheon. On the
Domination path, the best runes for Pantheon are
Zombie Ward and
Relentless Hunter.
Zombie Ward helps you to expand your vision on the map. Vision is very
crucial in LoL and helps you to avoid unnecessary deaths.
Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
FAQ for Pantheon Runes
Which is the best keystone rune on Pantheon?
The best keystone rune on Pantheon is
Conqueror. This Pantheon runes setup is then referred as Pantheon Conqueror.