Nidalee Runes explained
There's one set of runes for Nidalee on patch 14.10 that is the clear favorite for LoL players and pros alike. The best Nidalee rune paths on the position 
Jungle are 
Domination as the primary path and 
Sorcery as the secondary path with a pick rate of 50%. Besides picking runes on Nidalee you should learn how to play Nidalee and if you are interested in pro matches take a look on how a pro builds Nidalee. If you want to discuss 
Nidalee then you should visit the champion subreddit.
Nidalee runes from primary path
Domination improves burst damage and assassination tools on Nidalee. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Conqueror is the best keystone rune to run on Nidalee. This keystone rune provides additional power in the later stages of a game. As soon as Conqueror is fully charged, Nidalee deals additional damage and gains life steal. Other primary runes on Nidalee are Sudden Impact, Eyeball Collection and Treasure Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Nidalee with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives Nidalee additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Nidalee will gain an additional 70 gold for the first takedown. Nidalee acquires Bounty Hunter Stacks, which Nidalee may use to get more takedowns. This rune's power will grow tremendously, and Nidalee will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Nidalee will get an additional twenty gold.
Nidalee runes from secondary path
When it comes to your secondary path, most Nidalee players prefer to go with Sorcery. Sorcery empoweres abilities of Nidalee and increases the available champion resources. On the Sorcery path, the best runes for Nidalee are 
Waterwalking and 
Transcendence.
Waterwalking grants movement speed in the river, which helps Nidalee get around the map quicker. The extra damage will also help in those all important dragon and baron fights. Transcendence for some more Ability Haste.
FAQ for Nidalee Runes
Which is the best keystone rune on Nidalee?
The best keystone rune on Nidalee is Conqueror. This Nidalee runes setup is then referred as Nidalee Conqueror.
What runes does Nidalee use?
Runes from the paths Domination and Sorcery are the most used runes on Nidalee. For the exact pick rates of Nidalee runes used, you have to study the rune distribution presented.