Neeko Runes explained
There's one set of runes for Neeko on patch
11.19
that is the clear favorite for LoL players and pros alike. The best Neeko Runes on the position 
Top are Precision as the primary path and
Domination as the secondary path with a pick rate of 52%. Besides runes you should take a look on Neeko Build and if you are interested in pro matches take a look at Neeko Probuilds. If you want to discuss
Neeko then you should visit the champion subreddit.
Primary path on Neeko
Precision improves attack and sustained damage on Neeko troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Press the Attack is the best keystone rune to run on
Neeko. Neeko has a very easy time activating this rune with basic attacks which synergises well with
Press the Attack’s damage increase once activated. This is usually followed up by taking
Overheal,
Legend: Alacrity and
Coup de Grace.
Overheal converts healing in excess of maximum health of Neeko into a shield, which provides additional safty and tankiness.
Legend: Alacrity grants additional attack speed to Neeko. Neeko deals with
Coup de Grace more damage to targets with low health.
Secondary path on Neeko
When it comes to your secondary path, most
Neeko players prefer to go with
Domination.
Domination improves burst damage and assassination tools on Neeko. On the
Domination path, the best runes for Neeko are
Taste of Blood and
Ravenous Hunter.
Taste of Blood heals Neeko as soon as you damage an opposing champion.
Ravenous Hunter is the final rune of the
Domination path. This rune gives some survivability during short fights and damage trades during the laning phase. The additional health is nothing to scoff at and can mean the difference between winning or losing a battle.