Neeko Runes explained
There's one set of runes for Neeko on patch 14.23 that is the clear favorite for LoL players and pros alike. The best Neeko rune paths on the position 
Support are 
Sorcery as the primary path and 
Inspiration as the secondary path with a pick rate of 84%. Besides picking runes on Neeko you should learn how to play Neeko and if you are interested in pro matches take a look on how a pro builds Neeko. If you want to discuss 
Neeko then you should visit the champion subreddit.
Neeko runes from primary path
Sorcery empoweres abilities of Neeko and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Arcane Comet is the best keystone rune to run on Neeko. This keystone rune adds more damage to your abilities and increases your power in the laning phase. Other primary runes on Neeko are 
Manaflow Band, 
Absolute Focus and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Absolute Focus grants additional damage while Neeko is alomst full health. Scorch increases your control in the early game.
Neeko runes from secondary path
When it comes to your secondary path, most Neeko players prefer to go with Inspiration. Inspiration opens creative opportunities on Neeko troughout the match. On the Inspiration path, the best runes for Neeko are 
Cosmic Insight and 
Biscuit Delivery.
Cosmic Insight grants summoner spell and item haste. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
FAQ for Neeko Runes
Which is the best keystone rune on Neeko?
The best keystone rune on Neeko is Arcane Comet. This Neeko runes setup is then referred as Neeko Arcane Comet.
What runes does Neeko use?
Runes from the paths Sorcery and Inspiration are the most used runes on Neeko. For the exact pick rates of Neeko runes used, you have to study the rune distribution presented.