Nasus Runes explained
There's one set of runes for Nasus on patch 15.2 that is the clear favorite for LoL players and pros alike. The best Nasus rune paths on the position 
Top are 
Sorcery as the primary path and 
Resolve as the secondary path with a pick rate of 29%. Besides picking runes on Nasus you should learn how to play Nasus and if you are interested in pro matches take a look on how a pro builds Nasus. If you want to discuss 
Nasus then you should visit the champion subreddit.
Nasus runes from primary path
Sorcery empoweres abilities of Nasus and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Fleet Footwork is the best keystone rune to run on Nasus. This keystone rune generates you a lot of sustain and increases your survivability against poke champions in lane. Other primary runes on Nasus are 
Manaflow Band, 
Transcendence and 
Gathering Storm.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste. Gathering Storm increases your late game power.
Nasus runes from secondary path
When it comes to your secondary path, most Nasus players prefer to go with Resolve. Resolve empowers the survivability of Nasus and increases the tankiness. On the Resolve path, the best runes for Nasus are 
Second Wind and 
Demolish.
Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion. Demolish increases your pressure on the enemy turrets. This rune will help you to punish bad roams or backtimings of your lane opponent.
FAQ for Nasus Runes
Which is the best keystone rune on Nasus?
The best keystone rune on Nasus is Fleet Footwork. This Nasus runes setup is then referred as Nasus Fleet Footwork.
What runes does Nasus use?
Runes from the paths Sorcery and Resolve are the most used runes on Nasus. For the exact pick rates of Nasus runes used, you have to study the rune distribution presented.