Nasus Runes explained
There's one set of runes for Nasus on patch 14.21 that is the clear favorite for LoL players and pros alike. The best Nasus rune paths on the position 
Top are 
Sorcery as the primary path and Inspiration as the secondary path with a pick rate of 42%. Besides picking runes on Nasus you should learn how to play Nasus and if you are interested in pro matches take a look on how a pro builds Nasus. If you want to discuss 
Nasus then you should visit the champion subreddit.
Nasus runes from primary path
Sorcery empoweres abilities of Nasus and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Fleet Footwork is the best keystone rune to run on Nasus. This keystone rune generates you a lot of sustain and increases your survivability against poke champions in lane. Other primary runes on Nasus are Manaflow Band, Transcendence and Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste. Scorch increases your control in the early game.
Nasus runes from secondary path
When it comes to your secondary path, most Nasus players prefer to go with Inspiration. Inspiration opens creative opportunities on Nasus troughout the match. On the Inspiration path, the best runes for Nasus are Biscuit Delivery and Approach Velocity.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Nasus gains bonus movement speed by Approach Velocity, while moving toward enemy champions that are immobilized or slowed. This rune is perfect to follow up engages by your teammates.
FAQ for Nasus Runes
Which is the best keystone rune on Nasus?
The best keystone rune on Nasus is Fleet Footwork. This Nasus runes setup is then referred as Nasus Fleet Footwork.
What runes does Nasus use?
Runes from the paths Sorcery and Inspiration are the most used runes on Nasus. For the exact pick rates of Nasus runes used, you have to study the rune distribution presented.