Nasus Runes explained
There's one set of runes for Nasus on patch
12.18
that is the clear favorite for LoL players and pros alike. The best Nasus rune paths on the position 
Mid are Precision as the primary path and
Resolve as the secondary path with a pick rate of 75%. Besides picking runes on Nasus you should learn how to play Nasus and if you are interested in pro matches take a look on how a pro builds Nasus. If you want to discuss
Nasus then you should visit the champion subreddit.
Nasus runes from primary path
Precision improves attack and sustained damage on Nasus troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Fleet Footwork is the best keystone rune to run on
Nasus. This keystone rune generates you a lot of sustain and increases your survivability against poke champions in lane. Other primary runes on Nasus are
Presence of Mind,
Legend: Tenacity and
Last Stand.
Presence of Mind helps Nasus with the mana problems by restoring missing mana, if a champion is killed. Nasus gains extra Tenacity with every additional stage of
Legend: Tenacity. With
Last Stand you deal more damage while you are at low health.
Nasus runes from secondary path
When it comes to your secondary path, most
Nasus players prefer to go with
Resolve.
Resolve empowers the survivability of Nasus and increases the tankiness. On the
Resolve path, the best runes for Nasus are
Second Wind and
Overgrowth.
Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion.
Overgrowth increases your maximum amount of health.
FAQ for Nasus Runes
Which is the best keystone rune on Nasus?
The best keystone rune on Nasus is
Fleet Footwork. This Nasus runes setup is then referred as Nasus Fleet Footwork.
What runes does Nasus use?
Runes from the paths
Precision and
Resolve are the most used runes on Nasus. For the exact pick rates of Nasus runes used, you have to study the rune distribution presented.