Morgana Runes explained
There's one set of runes for Morgana on patch 15.14 that is the clear favorite for LoL players and pros alike. The best Morgana rune paths on the position 
Support are 
Inspiration as the primary path and 
Sorcery as the secondary path with a pick rate of 46%. Besides picking runes on Morgana you should learn how to play Morgana and if you are interested in pro matches take a look on how a pro builds Morgana. If you want to discuss 
Morgana then you should visit the champion subreddit.
Morgana runes from primary path
Inspiration opens creative opportunities on Morgana troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Unsealed Spellbook is the best keystone rune to run on Morgana. This keystone rune allows Morgana to create a one-time use summoner spell. The new summoner spell replaces one of their current summoner spells and remains available until it is used or replaced. Unsealed Spellbook has some unique rules in that a particular summoner spell cannot be selected again until three other unique spells have been taken. LoL pro players will often use Unsealed Spellbook to aid them in their current or upcoming situation. Are you about to fight the last dragon for a soul buff? Due to Unsealed Spellbook, Morgana can choose 
Smite to help their jungler secure the dragon for the team. There are numberless circumstances where a particular summoner spell can turn the game on its head, and that's where Unsealed Spellbook shines the most. Other primary runes on Morgana are 
Cash Back, 
Biscuit Delivery and 
Cosmic Insight.
You can enter debt to buy items, which is displayed as negative gold in your inventary. A small lending fee is added onto the amount of gold you owe after leaving the shop. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
Morgana runes from secondary path
When it comes to your secondary path, most Morgana players prefer to go with Sorcery. Sorcery empoweres abilities of Morgana and increases the available champion resources. On the Sorcery path, the best runes for Morgana are 
Manaflow Band and 
Transcendence.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste.
FAQ for Morgana Runes
Which is the best keystone rune on Morgana?
The best keystone rune on Morgana is Unsealed Spellbook. This Morgana runes setup is then referred as Morgana Unsealed Spellbook.
What runes does Morgana use?
Runes from the paths Inspiration and Sorcery are the most used runes on Morgana. For the exact pick rates of Morgana runes used, you have to study the rune distribution presented.