Miss Fortune Runes explained
There's one set of runes for Miss Fortune on patch
11.15
that is the clear favorite for LoL players and pros alike. The best Miss Fortune Runes on the position 
Adc are Domination as the primary path and
Precision as the secondary path with a pick rate of 28%. Besides runes you should take a look on Miss Fortune Build and if you are interested in pro matches take a look at Miss Fortune Probuilds. If you want to discuss
Miss Fortune then you should visit the champion subreddit.
Primary path on Miss Fortune
Domination improves burst damage and assassination tools on Miss Fortune. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Dark Harvest is the best keystone rune to run on
Miss Fortune. This keystone rune gives you additional damage throughout the match. This is usually followed up by taking
Cheap Shot,
Eyeball Collection and
Ravenous Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Miss Fortune.
Eyeball Collection is next up. This grants the user additional damage with every killing they score.
Ravenous Hunter is the final rune of the
Domination path. This rune gives some survivability during short fights and damage trades during the laning phase. The additional health is nothing to scoff at and can mean the difference between winning or losing a battle.
Secondary path on Miss Fortune
When it comes to your secondary path, most
Miss Fortune players prefer to go with
Precision.
Precision improves attack and sustained damage on Miss Fortune troughout the match. On the
Precision path, the best runes for MissFortune are
Legend: Bloodline and
Presence of Mind.
Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match.
Presence of Mind helps Miss Fortune with the mana problems by restoring missing mana, if a champion is killed.