Miss Fortune Runes explained
There's one set of runes for Miss Fortune on patch
12.9
that is the clear favorite for LoL players and pros alike. The best Miss Fortune Runes on the position 
Adc are Sorcery as the primary path and
Inspiration as the secondary path with a pick rate of 68%. Besides runes you should take a look on Miss Fortune Build and if you are interested in pro matches take a look at Miss Fortune Probuilds. If you want to discuss
Miss Fortune then you should visit the champion subreddit.
Primary runes path on Miss Fortune
Sorcery empoweres abilities of Miss Fortune and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Arcane Comet is the best keystone rune to run on
Miss Fortune. This keystone rune adds more damage to your abilities and increases your power in the laning phase. Other primary runes on Miss Fortune are
Manaflow Band,
Absolute Focus and
Scorch.
This is usually followed up by taking
Manaflow Band for additional mana and mana regenaration.
Absolute Focus grants additional damage while Miss Fortune is alomst full health.
Scorch increases your control in the early game.
Secondary runes path on Miss Fortune
When it comes to your secondary path, most
Miss Fortune players prefer to go with
Inspiration.
Inspiration opens creative opportunities on Miss Fortune troughout the match. On the
Inspiration path, the best runes for MissFortune are
Biscuit Delivery and
Magical Footwear.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
Magical Footwear allows Miss Fortune to focus on those essential core items without the need to spend the additional 300 gold on boots.
FAQ for Miss Fortune Runes
Which is the best keystone rune on Miss Fortune?
The best keystone rune on Miss Fortune is
Arcane Comet. This Miss Fortune runes setup is then referred as Miss Fortune Arcane Comet.