Miss Fortune Runes explained
There's one set of runes for Miss Fortune on patch
11.20
that is the clear favorite for LoL players and pros alike. The best Miss Fortune Runes on the position 
Adc are Precision as the primary path and
Inspiration as the secondary path with a pick rate of 39%. Besides runes you should take a look on Miss Fortune Build and if you are interested in pro matches take a look at Miss Fortune Probuilds. If you want to discuss
Miss Fortune then you should visit the champion subreddit.
Primary path on Miss Fortune
Precision improves attack and sustained damage on Miss Fortune troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Press the Attack is the best keystone rune to run on
Miss Fortune. Miss Fortune has a very easy time activating this rune with basic attacks which synergises well with
Press the Attack’s damage increase once activated. This is usually followed up by taking
Presence of Mind,
Legend: Bloodline and
Coup de Grace.
Presence of Mind helps Miss Fortune with the mana problems by restoring missing mana, if a champion is killed.
Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match. Miss Fortune deals with
Coup de Grace more damage to targets with low health.
Secondary path on Miss Fortune
When it comes to your secondary path, most
Miss Fortune players prefer to go with
Inspiration.
Inspiration opens creative opportunities on Miss Fortune troughout the match. On the
Inspiration path, the best runes for MissFortune are
Biscuit Delivery and
Magical Footwear.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
Magical Footwear allows players to focus on those essential core items without the need to spend the additional 300 gold on boots.
FAQ for Miss Fortune Runes
Which is the best keystone rune on Miss Fortune?
The best keystone rune on Miss Fortune is
Press the Attack.