Miss Fortune Runes explained
There's one set of runes for Miss Fortune on patch
11.8
that is the clear favorite for LoL players and pros alike. The best Miss Fortune Runes on the position 
Adc are Precision as the primary path and
Domination as the secondary path with a pick rate of 35%. Besides runes you should take a look on Miss Fortune Build and if you are interested in pro matches take a look at Miss Fortune Probuilds. If you want to discuss
Miss Fortune then you should visit the champion subreddit.
Primary path on Miss Fortune
Precision improves attack and sustained damage on Miss Fortune troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Press the Attack is the best keystone rune to run on
Miss Fortune. Miss Fortune has a very easy time activating this rune with basic attacks which synergises well with
Press the Attack’s damage increase once activated. This is usually followed up by taking
Overheal,
Legend: Bloodline and
Cut Down.
Overheal converts healing in excess of maximum health of Miss Fortune into a shield, which provides additional safty and tankiness.
Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match. If the enemy team consists of multiple tanks, then the rune
Cut Down is the best choice.
Secondary path on Miss Fortune
When it comes to your secondary path, most
Miss Fortune players prefer to go with
Domination.
Domination improves burst damage and assassination tools on Miss Fortune. On the
Domination path, the best runes for MissFortune are
Ravenous Hunter and
Taste of Blood.
Ravenous Hunter is the final rune of the
Domination path. This rune gives some survivability during short fights and damage trades during the laning phase. The additional health is nothing to scoff at and can mean the difference between winning or losing a battle.
Taste of Blood heals Miss Fortune as soon as you damage an opposing champion.