Milio Runes explained
There's one set of runes for Milio on patch 15.4 that is the clear favorite for LoL players and pros alike. The best Milio rune paths on the position 
Support are 
Domination as the primary path and 
Sorcery as the secondary path with a pick rate of 44%. Besides picking runes on Milio you should learn how to play Milio and if you are interested in pro matches take a look on how a pro builds Milio.
Milio runes from primary path
Domination improves burst damage and assassination tools on Milio. Most of high elo players – and our LoL pros in the the major regions – have agreed that Dark Harvest is the best keystone rune to run on 
Milio. This keystone rune gives you additional damage throughout the match. Other primary runes on Milio are Cheap Shot, Grisly Mementos and Treasure Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Milio. Treasure Hunter is the final rune of the Domination path. This rune gives Milio additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Milio will gain an additional 70 gold for the first takedown. Milio acquires Bounty Hunter Stacks, which Milio may use to get more takedowns. This rune's power will grow tremendously, and Milio will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Milio will get an additional twenty gold.
Milio runes from secondary path
When it comes to your secondary path, most Milio players prefer to go with Sorcery. Sorcery empoweres abilities of Milio and increases the available champion resources. On the Sorcery path, the best runes for Milio are 
Absolute Focus and 
Gathering Storm.
Absolute Focus grants additional damage while Milio is alomst full health. Gathering Storm increases your late game power.
FAQ for Milio Runes
Which is the best keystone rune on Milio?
The best keystone rune on Milio is Dark Harvest. This Milio runes setup is then referred as Milio Dark Harvest.
What runes does Milio use?
Runes from the paths Domination and Sorcery are the most used runes on Milio. For the exact pick rates of Milio runes used, you have to study the rune distribution presented.