Lucian Runes explained
There's one set of runes for Lucian on patch 13.1 that is the clear favorite for LoL players and pros alike. The best Lucian rune paths on the position 
Adc are 
Inspiration as the primary path and 
Sorcery as the secondary path with a pick rate of 57%. Besides picking runes on Lucian you should learn how to play Lucian and if you are interested in pro matches take a look on how a pro builds Lucian. If you want to discuss 
Lucian then you should visit the champion subreddit.
Lucian runes from primary path
Inspiration opens creative opportunities on Lucian troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
First Strike is the best keystone rune to run on Lucian. Other primary runes on Lucian are 
Magical Footwear, 
Biscuit Delivery and 
Cosmic Insight.
Magical Footwear allows Lucian to focus on those essential core items without the need to spend the additional 300 gold on boots. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
Lucian runes from secondary path
When it comes to your secondary path, most Lucian players prefer to go with Sorcery. Sorcery empoweres abilities of Lucian and increases the available champion resources. On the Sorcery path, the best runes for Lucian are 
Manaflow Band and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Scorch increases your control in the early game.
FAQ for Lucian Runes
Which is the best keystone rune on Lucian?
The best keystone rune on Lucian is First Strike. This Lucian runes setup is then referred as Lucian First Strike.
What runes does Lucian use?
Runes from the paths Inspiration and Sorcery are the most used runes on Lucian. For the exact pick rates of Lucian runes used, you have to study the rune distribution presented.