Lissandra Runes explained
There's one set of runes for Lissandra on patch
11.15
that is the clear favorite for LoL players and pros alike. The best Lissandra Runes on the position 
Mid are Resolve as the primary path and
Inspiration as the secondary path with a pick rate of 38%. Besides runes you should take a look on Lissandra Build and if you are interested in pro matches take a look at Lissandra Probuilds. If you want to discuss
Lissandra then you should visit the champion subreddit.
Primary path on Lissandra
Resolve empowers the survivability of Lissandra and increases the tankiness. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Aftershock is the best keystone rune to run on
Lissandra. This keystone rune bulks you up, increasing both armour and magic resistance, once you immobilized a champion.
Aftershock synergises both with the sheer amount of crowd control Lissandra possesses and the need to be tanky as soon as you engage. This is usually followed up by taking
Demolish,
Bone Plating and
Unflinching.
Demolish increases your pressure on the enemy turrets. This rune will help you to punish bad roams or backtimings of your lane opponent.
Bone Plating make Lissandra overall tankier, by decreasing the amount of poke damage in the early game.
Unflinching inceases Lissandra tenacity based on your missing health.
Secondary path on Lissandra
When it comes to your secondary path, most
Lissandra players prefer to go with
Inspiration.
Inspiration opens creative opportunities on Lissandra troughout the match. On the
Inspiration path, the best runes for Lissandra are
Biscuit Delivery and
Time Warp Tonic.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
Time Warp Tonic gives you additional sustain by boosting your
