Lissandra Runes explained
There's one set of runes for Lissandra on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Lissandra rune paths on the position 
Mid are 
Sorcery as the primary path and 
Inspiration as the secondary path with a pick rate of 55%. Besides picking runes on Lissandra you should learn how to play Lissandra and if you are interested in pro matches take a look on how a pro builds Lissandra. If you want to discuss 
Lissandra then you should visit the champion subreddit.
Lissandra runes from primary path
Sorcery empoweres abilities of Lissandra and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Arcane Comet is the best keystone rune to run on Lissandra. This keystone rune adds more damage to your abilities and increases your power in the laning phase. Other primary runes on Lissandra are 
Manaflow Band, 
Transcendence and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste. Scorch increases your control in the early game.
Lissandra runes from secondary path
When it comes to your secondary path, most Lissandra players prefer to go with Inspiration. Inspiration opens creative opportunities on Lissandra troughout the match. On the Inspiration path, the best runes for Lissandra are Biscuit Delivery and Cosmic Insight.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
FAQ for Lissandra Runes
Which is the best keystone rune on Lissandra?
The best keystone rune on Lissandra is Arcane Comet. This Lissandra runes setup is then referred as Lissandra Arcane Comet.
What runes does Lissandra use?
Runes from the paths Sorcery and Inspiration are the most used runes on Lissandra. For the exact pick rates of Lissandra runes used, you have to study the rune distribution presented.