Lissandra Runes explained
There's one set of runes for Lissandra on patch
11.7
that is the clear favorite for LoL players and pros alike. The best Lissandra Runes on the position 
Mid are Domination as the primary path and
Inspiration as the secondary path with a pick rate of 37%. Besides runes you should take a look on Lissandra Build and if you are interested in pro matches take a look at Lissandra Probuilds. If you want to discuss
Lissandra then you should visit the champion subreddit.
Primary path on Lissandra
Domination improves burst damage and assassination tools on Lissandra. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Electrocute is the best keystone rune to run on
Lissandra. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. This is usually followed up by taking
Taste of Blood,
Eyeball Collection and
Ultimate Hunter.
Taste of Blood heals Lissandra as soon as you damage an opposing champion.
Eyeball Collection is next up. This grants the user additional damage with every killing they score.
Ultimate Hunter scales up Lissandra ultimate haste on every unique champion takedown.
Secondary path on Lissandra
When it comes to your secondary path, most
Lissandra players prefer to go with
Inspiration.
Inspiration opens creative opportunities on Lissandra troughout the match. On the
Inspiration path, the best runes for Lissandra are
Biscuit Delivery and
Cosmic Insight.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
Cosmic Insight grants summoner spell and item haste.