Leona Runes explained
There's one set of runes for Leona on patch 14.12 that is the clear favorite for LoL players and pros alike. The best Leona rune paths on the position 
Support are 
Resolve as the primary path and 
Inspiration as the secondary path with a pick rate of 73%. Besides picking runes on Leona you should learn how to play Leona and if you are interested in pro matches take a look on how a pro builds Leona. If you want to discuss 
Leona then you should visit the champion subreddit.
Leona runes from primary path
Resolve empowers the survivability of Leona and increases the tankiness. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Aftershock is the best keystone rune to run on Leona. This keystone rune bulks you up, increasing both armour and magic resistance, once you immobilized a champion. Aftershock synergises both with the sheer amount of crowd control Leona possesses and the need to be tanky as soon as you engage. Other primary runes on Leona are 
Font of Life, 
Bone Plating and 
Overgrowth.
Font of Life provides your teammates with more sustain by healing them whenever they attack a champion whose movement you've recently impaired. Bone Plating make Leona overall tankier, by decreasing the amount of poke damage in the early game. Overgrowth increases your maximum amount of health.
Leona runes from secondary path
When it comes to your secondary path, most Leona players prefer to go with Inspiration. Inspiration opens creative opportunities on Leona troughout the match. On the Inspiration path, the best runes for Leona are 
Cosmic Insight and 
Hextech Flashtraption.
Cosmic Insight grants summoner spell and item haste. Having an extra way to decrease the distance with the Hextech Flashtraption will make an engage much easier to pull off.
FAQ for Leona Runes
Which is the best keystone rune on Leona?
The best keystone rune on Leona is Aftershock. This Leona runes setup is then referred as Leona Aftershock.
What runes does Leona use?
Runes from the paths Resolve and Inspiration are the most used runes on Leona. For the exact pick rates of Leona runes used, you have to study the rune distribution presented.