Katarina Runes explained
There's one set of runes for Katarina on patch
12.15
that is the clear favorite for LoL players and pros alike. The best Katarina rune paths on the position 
Mid are Inspiration as the primary path and
Domination as the secondary path with a pick rate of 36%. Besides picking runes on Katarina you should learn how to play Katarina and if you are interested in pro matches take a look on how a pro builds Katarina. If you want to discuss
Katarina then you should visit the champion subreddit.
Katarina runes from primary path
Inspiration opens creative opportunities on Katarina troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that
First Strike is the best keystone rune to run on
Katarina. Other primary runes on Katarina are
Magical Footwear,
Future's Market and
Cosmic Insight.
Magical Footwear allows Katarina to focus on those essential core items without the need to spend the additional 300 gold on boots. You can enter debt to buy items, which is displayed as negative gold in your inventary. A small lending fee is added onto the amount of gold you owe after leaving the shop.
Cosmic Insight grants summoner spell and item haste.
Katarina runes from secondary path
When it comes to your secondary path, most
Katarina players prefer to go with
Domination.
Domination improves burst damage and assassination tools on Katarina. On the
Domination path, the best runes for Katarina are
Sudden Impact and
Relentless Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Katarina with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier.
Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
FAQ for Katarina Runes
Which is the best keystone rune on Katarina?
The best keystone rune on Katarina is
First Strike. This Katarina runes setup is then referred as Katarina First Strike.
What runes does Katarina use?
Runes from the paths
Inspiration and
Domination are the most used runes on Katarina. For the exact pick rates of Katarina runes used, you have to study the rune distribution presented.