Karthus Runes
B
Jungle

Karthus Runes

Death Defied
Lay Waste
Q
Wall of Pain
W
Defile
E
Requiem
R
Mage
Mage
6/0
Win/Loss
<1%
Pick Rate
20%
Ban Rate

Domination + Precision as Karthus Runes

1
2
3
Domination
Domination
Electrocute
0%
Predator
0%
Dark Harvest
100%
Hail of Blades
0%
Cheap Shot
94%
Taste of Blood
6%
Sudden Impact
0%
Zombie Ward
2%
Ghost Poro
0%
Eyeball Collection
98%
Ravenous Hunter
94%
Ingenious Hunter
0%
Relentless Hunter
0%
Ultimate Hunter
6%
Precision
Precision
Overheal
0%
Triumph
0%
Presence of Mind
100%
Legend: Alacrity
0%
Legend: Tenacity
0%
Legend: Bloodline
0%
Coup de Grace
56%
Cut Down
<1%
Last Stand
44%
Offense
94%
Offense
0%
Offense
6%
Offense
>99%
Flex
0%
Flex
0%
Defense
0%
Flex
77%
Flex
24%
73%
51

Karthus Runes explained

There's one set of runes for Karthus on patch

11.8
that is the clear favorite for LoL players and pros alike. The best Karthus Runes on the position Jungle Jungle are
Domination
Domination as the primary path and
Precision
Precision as the secondary path with a pick rate of 79%. Besides runes you should take a look on Karthus Build and if you are interested in pro matches take a look at Karthus Probuilds. If you want to discuss
Karthus
Karthus then you should visit the champion subreddit.

Primary path on Karthus

Domination
Domination improves burst damage and assassination tools on Karthus. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Dark Harvest
Dark Harvest is the best keystone rune to run on
Karthus
Karthus. This keystone rune gives you additional damage throughout the match. This is usually followed up by taking
Cheap Shot
Cheap Shot,
Eyeball Collection
Eyeball Collection and
Ravenous Hunter
Ravenous Hunter.

Cheap Shot
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Karthus.
Eyeball Collection
Eyeball Collection is next up. This grants the user additional damage with every killing they score.
Ravenous Hunter
Ravenous Hunter is the final rune of the
Domination
Domination path. This rune gives some survivability during short fights and damage trades during the laning phase. The additional health is nothing to scoff at and can mean the difference between winning or losing a battle.

Secondary path on Karthus

When it comes to your secondary path, most

Karthus
Karthus players prefer to go with
Precision
Precision.
Precision
Precision improves attack and sustained damage on Karthus troughout the match. On the
Precision
Precision path, the best runes for Karthus are
Presence of Mind
Presence of Mind and
Coup de Grace
Coup de Grace.

Presence of Mind
Presence of Mind helps Karthus with the mana problems by restoring missing mana, if a champion is killed. Karthus deals with
Coup de Grace
Coup de Grace more damage to targets with low health.