Hwei Runes explained
There's one set of runes for Hwei on patch 14.16 that is the clear favorite for LoL players and pros alike. The best Hwei rune paths on the position 
Mid are 
Sorcery as the primary path and 
Inspiration as the secondary path with a pick rate of 65%. Besides picking runes on Hwei you should learn how to play Hwei and if you are interested in pro matches take a look on how a pro builds Hwei.
Hwei runes from primary path
Sorcery empoweres abilities of Hwei and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Arcane Comet is the best keystone rune to run on 
Hwei. This keystone rune adds more damage to your abilities and increases your power in the laning phase. Other primary runes on Hwei are 
Manaflow Band, 
Transcendence and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste. Scorch increases your control in the early game.
Hwei runes from secondary path
When it comes to your secondary path, most Hwei players prefer to go with Inspiration. Inspiration opens creative opportunities on Hwei troughout the match. On the Inspiration path, the best runes for Hwei are Biscuit Delivery and Cosmic Insight.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
FAQ for Hwei Runes
Which is the best keystone rune on Hwei?
The best keystone rune on Hwei is Arcane Comet. This Hwei runes setup is then referred as Hwei Arcane Comet.
What runes does Hwei use?
Runes from the paths Sorcery and Inspiration are the most used runes on Hwei. For the exact pick rates of Hwei runes used, you have to study the rune distribution presented.