Galio Runes explained
There's one set of runes for Galio on patch
12.10
that is the clear favorite for LoL players and pros alike. The best Galio Runes on the position 
Mid are Domination as the primary path and
Resolve as the secondary path with a pick rate of 36%. Besides runes you should take a look on Galio Build and if you are interested in pro matches take a look at Galio Probuilds. If you want to discuss
Galio then you should visit the champion subreddit.
Primary runes path on Galio
Domination improves burst damage and assassination tools on Galio. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Predator is the best keystone rune to run on
Galio. As soon as you buy
Predator. After a short cast time Galio gains bonus movement speed, while moving toward enemy champions. This keystone rune is perfect for roaming and ganking. Other primary runes on Galio are
Taste of Blood,
Eyeball Collection and
Ingenious Hunter.
Taste of Blood heals Galio as soon as you damage an opposing champion.
Eyeball Collection is next up. This grants the user additional damage with every killing they score.
Ingenious Hunter gives you item haste on every unique champion takedown.
Secondary runes path on Galio
When it comes to your secondary path, most
Galio players prefer to go with
Resolve.
Resolve empowers the survivability of Galio and increases the tankiness. On the
Resolve path, the best runes for Galio are
Unflinching and
Bone Plating.
Unflinching inceases Galio tenacity based on your missing health.
Bone Plating make Galio overall tankier, by decreasing the amount of poke damage in the early game.
FAQ for Galio Runes
Which is the best keystone rune on Galio?
The best keystone rune on Galio is
Predator. This Galio runes setup is then referred as Galio Predator.