Galio Runes explained
There's one set of runes for Galio on patch 15.14 that is the clear favorite for LoL players and pros alike. The best Galio rune paths on the position 
Mid are 
Sorcery as the primary path and 
Resolve as the secondary path with a pick rate of 72%. Besides picking runes on Galio you should learn how to play Galio and if you are interested in pro matches take a look on how a pro builds Galio. If you want to discuss 
Galio then you should visit the champion subreddit.
Galio runes from primary path
Sorcery empoweres abilities of Galio and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Phase Rush is the best keystone rune to run on Galio. Phase Rush offers more flexibility and options to betake oneself in and out of danger, which can be helpful since that's essentially the main playstyle of Galio. Other primary runes on Galio are 
Manaflow Band, 
Transcendence and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste. Scorch increases your control in the early game.
Galio runes from secondary path
When it comes to your secondary path, most Galio players prefer to go with Resolve. Resolve empowers the survivability of Galio and increases the tankiness. On the Resolve path, the best runes for Galio are 
Second Wind and 
Overgrowth.
Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion. Overgrowth increases your maximum amount of health.
FAQ for Galio Runes
Which is the best keystone rune on Galio?
The best keystone rune on Galio is Phase Rush. This Galio runes setup is then referred as Galio Phase Rush.
What runes does Galio use?
Runes from the paths Sorcery and Resolve are the most used runes on Galio. For the exact pick rates of Galio runes used, you have to study the rune distribution presented.