Fizz Runes explained
There's one set of runes for Fizz on patch 14.16 that is the clear favorite for LoL players and pros alike. The best Fizz rune paths on the position 
Mid are 
Domination as the primary path and 
Precision as the secondary path with a pick rate of 58%. Besides picking runes on Fizz you should learn how to play Fizz and if you are interested in pro matches take a look on how a pro builds Fizz. If you want to discuss 
Fizz then you should visit the champion subreddit.
Fizz runes from primary path
Domination improves burst damage and assassination tools on Fizz. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Electrocute is the best keystone rune to run on Fizz. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on Fizz are 
Sudden Impact, 
Eyeball Collection and 
Treasure Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Fizz with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives Fizz additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Fizz will gain an additional 70 gold for the first takedown. Fizz acquires Bounty Hunter Stacks, which Fizz may use to get more takedowns. This rune's power will grow tremendously, and Fizz will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Fizz will get an additional twenty gold.
Fizz runes from secondary path
When it comes to your secondary path, most Fizz players prefer to go with Precision. Precision improves attack and sustained damage on Fizz troughout the match. On the Precision path, the best runes for Fizz are 
Coup de Grace and 
Triumph.
Fizz deals with Coup de Grace more damage to targets with low health. Triumph restores on Fizz a part of missing health and award bonus gold, if a champion is killed.
FAQ for Fizz Runes
Which is the best keystone rune on Fizz?
The best keystone rune on Fizz is Electrocute. This Fizz runes setup is then referred as Fizz Electrocute.
What runes does Fizz use?
Runes from the paths Domination and Precision are the most used runes on Fizz. For the exact pick rates of Fizz runes used, you have to study the rune distribution presented.