Fiddlesticks Runes explained
There's one set of runes for Fiddlesticks on patch
12.15
that is the clear favorite for LoL players and pros alike. The best Fiddlesticks rune paths on the position 
Jungle are Domination as the primary path and
Inspiration as the secondary path with a pick rate of 63%. Besides picking runes on Fiddlesticks you should learn how to play Fiddlesticks and if you are interested in pro matches take a look on how a pro builds Fiddlesticks. If you want to discuss
Fiddlesticks then you should visit the champion subreddit.
Fiddlesticks runes from primary path
Domination improves burst damage and assassination tools on Fiddlesticks. Most of high elo players – and our LoL pros in the the major regions – have agreed that
First Strike is the best keystone rune to run on
Fiddlesticks. Other primary runes on Fiddlesticks are
Cheap Shot,
Eyeball Collection and
Ultimate Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Fiddlesticks.
Eyeball Collection is next up. This grants the user additional damage with every killing they score.
Ultimate Hunter scales up Fiddlesticks ultimate haste on every unique champion takedown.
Fiddlesticks runes from secondary path
When it comes to your secondary path, most
Fiddlesticks players prefer to go with
Inspiration.
Inspiration opens creative opportunities on Fiddlesticks troughout the match. On the
Inspiration path, the best runes for Fiddlesticks are
Cosmic Insight and
Future's Market.
Cosmic Insight grants summoner spell and item haste. You can enter debt to buy items, which is displayed as negative gold in your inventary. A small lending fee is added onto the amount of gold you owe after leaving the shop.
FAQ for Fiddlesticks Runes
Which is the best keystone rune on Fiddlesticks?
The best keystone rune on Fiddlesticks is
First Strike. This Fiddlesticks runes setup is then referred as Fiddlesticks First Strike.
What runes does Fiddlesticks use?
Runes from the paths
Domination and
Inspiration are the most used runes on Fiddlesticks. For the exact pick rates of Fiddlesticks runes used, you have to study the rune distribution presented.