Ezreal Runes explained
There's one set of runes for Ezreal on patch 14.10 that is the clear favorite for LoL players and pros alike. The best Ezreal rune paths on the position 
Adc are 
Precision as the primary path and 
Inspiration as the secondary path with a pick rate of 92%. Besides picking runes on Ezreal you should learn how to play Ezreal and if you are interested in pro matches take a look on how a pro builds Ezreal. If you want to discuss 
Ezreal then you should visit the champion subreddit.
Ezreal runes from primary path
Precision improves attack and sustained damage on Ezreal troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Conqueror is the best keystone rune to run on Ezreal. This keystone rune provides additional power in the later stages of a game. As soon as Conqueror is fully charged, Ezreal deals additional damage and gains life steal. Other primary runes on Ezreal are 
Presence of Mind, 
Legend: Bloodline and 
Coup de Grace.
Presence of Mind helps Ezreal with the mana problems by restoring missing mana, if a champion is killed. Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match. Ezreal deals with Coup de Grace more damage to targets with low health.
Ezreal runes from secondary path
When it comes to your secondary path, most Ezreal players prefer to go with Inspiration. Inspiration opens creative opportunities on Ezreal troughout the match. On the Inspiration path, the best runes for Ezreal are 
Biscuit Delivery and 
Magical Footwear.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Magical Footwear allows Ezreal to focus on those essential core items without the need to spend the additional 300 gold on boots.
FAQ for Ezreal Runes
Which is the best keystone rune on Ezreal?
The best keystone rune on Ezreal is Conqueror. This Ezreal runes setup is then referred as Ezreal Conqueror.
What runes does Ezreal use?
Runes from the paths Precision and Inspiration are the most used runes on Ezreal. For the exact pick rates of Ezreal runes used, you have to study the rune distribution presented.