Elise Runes explained
There's one set of runes for Elise on patch 14.12 that is the clear favorite for LoL players and pros alike. The best Elise rune paths on the position 
Jungle are 
Domination as the primary path and 
Sorcery as the secondary path with a pick rate of 40%. Besides picking runes on Elise you should learn how to play Elise and if you are interested in pro matches take a look on how a pro builds Elise. If you want to discuss 
Elise then you should visit the champion subreddit.
Elise runes from primary path
Domination improves burst damage and assassination tools on Elise. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Electrocute is the best keystone rune to run on Elise. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on Elise are 
Cheap Shot, 
Eyeball Collection and 
Relentless Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Elise. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Elise runes from secondary path
When it comes to your secondary path, most Elise players prefer to go with Sorcery. Sorcery empoweres abilities of Elise and increases the available champion resources. On the Sorcery path, the best runes for Elise are 
Waterwalking and 
Absolute Focus.
Waterwalking grants movement speed in the river, which helps Elise get around the map quicker. The extra damage will also help in those all important dragon and baron fights. Absolute Focus grants additional damage while Elise is alomst full health.
FAQ for Elise Runes
Which is the best keystone rune on Elise?
The best keystone rune on Elise is Electrocute. This Elise runes setup is then referred as Elise Electrocute.
What runes does Elise use?
Runes from the paths Domination and Sorcery are the most used runes on Elise. For the exact pick rates of Elise runes used, you have to study the rune distribution presented.