Cassiopeia Runes
D
Mid

Cassiopeia Runes

Serpentine Grace
Noxious Blast
Q
Miasma
W
Twin Fang
E
Petrifying Gaze
R
Mage
Mage
2/3
Win/Loss
<1%
Pick Rate
<1%
Ban Rate

Precision + Domination as Cassiopeia Runes

1
2
3
Precision
Precision
Press the Attack
0%
Lethal Tempo
0%
Fleet Footwork
0%
Conqueror
100%
Overheal
0%
Triumph
0%
Presence of Mind
100%
Legend: Alacrity
3%
Legend: Tenacity
97%
Legend: Bloodline
0%
Coup de Grace
45%
Cut Down
1%
Last Stand
53%
Domination
Domination
Cheap Shot
0%
Taste of Blood
100%
Sudden Impact
0%
Zombie Ward
0%
Ghost Poro
1%
Eyeball Collection
0%
Ravenous Hunter
99%
Ingenious Hunter
0%
Relentless Hunter
0%
Ultimate Hunter
0%
Offense
32%
Offense
19%
Offense
49%
Offense
100%
Flex
0%
Flex
0%
Defense
1%
Flex
37%
Flex
61%
78%
20

Cassiopeia Runes explained

There's one set of runes for Cassiopeia on patch

11.9
that is the clear favorite for LoL players and pros alike. The best Cassiopeia Runes on the position Mid Mid are
Precision
Precision as the primary path and
Domination
Domination as the secondary path with a pick rate of 76%. Besides runes you should take a look on Cassiopeia Build and if you are interested in pro matches take a look at Cassiopeia Probuilds. If you want to discuss
Cassiopeia
Cassiopeia then you should visit the champion subreddit.

Primary path on Cassiopeia

Precision
Precision improves attack and sustained damage on Cassiopeia troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Conqueror
Conqueror is the best keystone rune to run on
Cassiopeia
Cassiopeia. This keystone rune provides additional power in the later stages of a game. As soon as
Conqueror
Conqueror is fully charged, Cassiopeia deals additional damage and gains life steal. This is usually followed up by taking
Presence of Mind
Presence of Mind,
Legend: Tenacity
Legend: Tenacity and
Coup de Grace
Coup de Grace.

Presence of Mind
Presence of Mind helps Cassiopeia with the mana problems by restoring missing mana, if a champion is killed. Cassiopeia gains extra Tenacity with every additional stage of
Legend: Tenacity
Legend: Tenacity. Cassiopeia deals with
Coup de Grace
Coup de Grace more damage to targets with low health.

Secondary path on Cassiopeia

When it comes to your secondary path, most

Cassiopeia
Cassiopeia players prefer to go with
Domination
Domination.
Domination
Domination improves burst damage and assassination tools on Cassiopeia. On the
Domination
Domination path, the best runes for Cassiopeia are
Taste of Blood
Taste of Blood and
Ravenous Hunter
Ravenous Hunter.

Taste of Blood
Taste of Blood heals Cassiopeia as soon as you damage an opposing champion.
Ravenous Hunter
Ravenous Hunter is the final rune of the
Domination
Domination path. This rune gives some survivability during short fights and damage trades during the laning phase. The additional health is nothing to scoff at and can mean the difference between winning or losing a battle.