Brand Runes explained
There's one set of runes for Brand on patch
11.21
that is the clear favorite for LoL players and pros alike. The best Brand Runes on the position 
Adc are Domination as the primary path and
Precision as the secondary path with a pick rate of 71%. Besides runes you should take a look on Brand Build and if you are interested in pro matches take a look at Brand Probuilds. If you want to discuss
Brand then you should visit the champion subreddit.
Primary path on Brand
Domination improves burst damage and assassination tools on Brand. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Dark Harvest is the best keystone rune to run on
Brand. This keystone rune gives you additional damage throughout the match. This is usually followed up by taking
Cheap Shot,
Eyeball Collection and
Ultimate Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Brand.
Eyeball Collection is next up. This grants the user additional damage with every killing they score.
Ultimate Hunter scales up Brand ultimate haste on every unique champion takedown.
Secondary path on Brand
When it comes to your secondary path, most
Brand players prefer to go with
Precision.
Precision improves attack and sustained damage on Brand troughout the match. On the
Precision path, the best runes for Brand are
Presence of Mind and
Cut Down.
Presence of Mind helps Brand with the mana problems by restoring missing mana, if a champion is killed. If the enemy team consists of multiple tanks, then the rune
Cut Down is the best choice.
FAQ for Brand Runes
Which is the best keystone rune on Brand?
The best keystone rune on Brand is
Dark Harvest.