Aurelion Sol Runes explained
There's one set of runes for Aurelion Sol on patch
11.15
that is the clear favorite for LoL players and pros alike. The best Aurelion Sol Runes on the position 
Mid are Domination as the primary path and
Inspiration as the secondary path with a pick rate of 64%. Besides runes you should take a look on Aurelion Sol Build and if you are interested in pro matches take a look at Aurelion Sol Probuilds. If you want to discuss
Aurelion Sol then you should visit the champion subreddit.
Primary path on Aurelion Sol
Domination improves burst damage and assassination tools on Aurelion Sol. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Electrocute is the best keystone rune to run on
Aurelion Sol. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. This is usually followed up by taking
Taste of Blood,
Eyeball Collection and
Relentless Hunter.
Taste of Blood heals Aurelion Sol as soon as you damage an opposing champion.
Eyeball Collection is next up. This grants the user additional damage with every killing they score.
Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Secondary path on Aurelion Sol
When it comes to your secondary path, most
Aurelion Sol players prefer to go with
Inspiration.
Inspiration opens creative opportunities on Aurelion Sol troughout the match. On the
Inspiration path, the best runes for AurelionSol are
Time Warp Tonic and
Biscuit Delivery.
Time Warp Tonic gives you additional sustain by boosting your
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.