Ashe Runes explained
There's one set of runes for Ashe on patch 15.12 that is the clear favorite for LoL players and pros alike. The best Ashe rune paths on the position 
Adc are 
Precision as the primary path and 
Inspiration as the secondary path with a pick rate of 97%. Besides picking runes on Ashe you should learn how to play Ashe and if you are interested in pro matches take a look on how a pro builds Ashe. If you want to discuss 
Ashe then you should visit the champion subreddit.
Ashe runes from primary path
Precision improves attack and sustained damage on Ashe troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Lethal Tempo is the best keystone rune to run on Ashe. This keystone rune gives Ashe a great head start in team fights and allows to put out more damage in that time window. Other primary runes on Ashe are 
Presence of Mind, 
Legend: Alacrity and 
Cut Down.
Presence of Mind helps Ashe with the mana problems by restoring missing mana, if a champion is killed. Legend: Alacrity grants additional attack speed to Ashe. If the enemy team consists of multiple tanks, then the rune Cut Down is the best choice.
Ashe runes from secondary path
When it comes to your secondary path, most Ashe players prefer to go with Inspiration. Inspiration opens creative opportunities on Ashe troughout the match. On the Inspiration path, the best runes for Ashe are 
Approach Velocity and 
Biscuit Delivery.
Ashe gains bonus movement speed by Approach Velocity, while moving toward enemy champions that are immobilized or slowed. This rune is perfect to follow up engages by your teammates. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
FAQ for Ashe Runes
Which is the best keystone rune on Ashe?
The best keystone rune on Ashe is Lethal Tempo. This Ashe runes setup is then referred as Ashe Lethal Tempo.
What runes does Ashe use?
Runes from the paths Precision and Inspiration are the most used runes on Ashe. For the exact pick rates of Ashe runes used, you have to study the rune distribution presented.