Ashe Runes explained
There's one set of runes for Ashe on patch
11.15
that is the clear favorite for LoL players and pros alike. The best Ashe Runes on the position 
Adc are Domination as the primary path and
Inspiration as the secondary path with a pick rate of 60%. Besides runes you should take a look on Ashe Build and if you are interested in pro matches take a look at Ashe Probuilds. If you want to discuss
Ashe then you should visit the champion subreddit.
Primary path on Ashe
Domination improves burst damage and assassination tools on Ashe. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Hail of Blades is the best keystone rune to run on
Ashe. This keystone rune helps you to win short damage trades in your lane by increasing your attackspeed at the beginning of a fight. This is usually followed up by taking
Cheap Shot,
Eyeball Collection and
Ravenous Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Ashe.
Eyeball Collection is next up. This grants the user additional damage with every killing they score.
Ravenous Hunter is the final rune of the
Domination path. This rune gives some survivability during short fights and damage trades during the laning phase. The additional health is nothing to scoff at and can mean the difference between winning or losing a battle.
Secondary path on Ashe
When it comes to your secondary path, most
Ashe players prefer to go with
Inspiration.
Inspiration opens creative opportunities on Ashe troughout the match. On the
Inspiration path, the best runes for Ashe are
Biscuit Delivery and
Approach Velocity.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Ashe gains bonus movement speed by
Approach Velocity, while moving toward enemy champions that are immobilized or slowed. This rune is perfect to follow up engages by your teammates.