Annie Runes explained
There's one set of runes for Annie on patch
11.19
that is the clear favorite for LoL players and pros alike. The best Annie Runes on the position 
Mid are Domination as the primary path and
Sorcery as the secondary path with a pick rate of 57%. Besides runes you should take a look on Annie Build and if you are interested in pro matches take a look at Annie Probuilds. If you want to discuss
Annie then you should visit the champion subreddit.
Primary path on Annie
Domination improves burst damage and assassination tools on Annie. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Electrocute is the best keystone rune to run on
Annie. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. This is usually followed up by taking
Taste of Blood,
Eyeball Collection and
Relentless Hunter.
Taste of Blood heals Annie as soon as you damage an opposing champion.
Eyeball Collection is next up. This grants the user additional damage with every killing they score.
Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Secondary path on Annie
When it comes to your secondary path, most
Annie players prefer to go with
Sorcery.
Sorcery empoweres abilities of Annie and increases the available champion resources. On the
Sorcery path, the best runes for Annie are
Transcendence and
Manaflow Band.
Transcendence for some more Ability Haste. This is usually followed up by taking
Manaflow Band for additional mana and mana regenaration.