Akshan Runes explained
There's one set of runes for Akshan on patch
11.17
that is the clear favorite for LoL players and pros alike. The best Akshan Runes on the position 
Mid are Precision as the primary path and
Resolve as the secondary path with a pick rate of 61%. Besides runes you should take a look on Akshan Build and if you are interested in pro matches take a look at Akshan Probuilds. If you want to discuss
Akshan then you should visit the champion subreddit.
Primary path on Akshan
Precision improves attack and sustained damage on Akshan troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that
Press the Attack is the best keystone rune to run on
Akshan. Akshan has a very easy time activating this rune with basic attacks which synergises well with
Press the Attack’s damage increase once activated. This is usually followed up by taking
Presence of Mind,
Legend: Bloodline and
Coup de Grace.
Presence of Mind helps Akshan with the mana problems by restoring missing mana, if a champion is killed.
Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match. Akshan deals with
Coup de Grace more damage to targets with low health.
Secondary path on Akshan
When it comes to your secondary path, most
Akshan players prefer to go with
Resolve.
Resolve empowers the survivability of Akshan and increases the tankiness. On the
Resolve path, the best runes for Akshan are
Bone Plating and
Shield Bash.
Bone Plating make Akshan overall tankier, by decreasing the amount of poke damage in the early game.
Shield Bash powers up your tankiness and empowers your next basic attack while you have a shield.