Akshan Runes explained
There's one set of runes for Akshan on patch 14.21 that is the clear favorite for LoL players and pros alike. The best Akshan rune paths on the position 
Top are 
Precision as the primary path and 
Resolve as the secondary path with a pick rate of 76%. Besides picking runes on Akshan you should learn how to play Akshan and if you are interested in pro matches take a look on how a pro builds Akshan. If you want to discuss 
Akshan then you should visit the champion subreddit.
Akshan runes from primary path
Precision improves attack and sustained damage on Akshan troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Press the Attack is the best keystone rune to run on Akshan. Akshan has a very easy time activating this rune with basic attacks which synergises well with Press the Attack’s damage increase once activated. Other primary runes on Akshan are 
Presence of Mind, 
Legend: Alacrity and 
Cut Down.
Presence of Mind helps Akshan with the mana problems by restoring missing mana, if a champion is killed. Legend: Alacrity grants additional attack speed to Akshan. If the enemy team consists of multiple tanks, then the rune Cut Down is the best choice.
Akshan runes from secondary path
When it comes to your secondary path, most Akshan players prefer to go with Resolve. Resolve empowers the survivability of Akshan and increases the tankiness. On the Resolve path, the best runes for Akshan are 
Overgrowth and 
Bone Plating.
Overgrowth increases your maximum amount of health. Bone Plating make Akshan overall tankier, by decreasing the amount of poke damage in the early game.
FAQ for Akshan Runes
Which is the best keystone rune on Akshan?
The best keystone rune on Akshan is Press the Attack. This Akshan runes setup is then referred as Akshan Press the Attack.
What runes does Akshan use?
Runes from the paths Precision and Resolve are the most used runes on Akshan. For the exact pick rates of Akshan runes used, you have to study the rune distribution presented.