Shyvana Runes explained
There's one set of runes for Shyvana on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Shyvana rune paths on the position 
Jungle are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 50%. Besides picking runes on Shyvana you should learn how to play Shyvana and if you are interested in pro matches take a look on how a pro builds Shyvana. If you want to discuss 
Shyvana then you should visit the champion subreddit.
Shyvana runes from primary path
Domination improves burst damage and assassination tools on Shyvana. Most of high elo players – and our LoL pros in the the major regions – have agreed that Dark Harvest is the best keystone rune to run on Shyvana. This keystone rune gives you additional damage throughout the match. Other primary runes on Shyvana are Cheap Shot, Eyeball Collection and Relentless Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Shyvana. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Shyvana runes from secondary path
When it comes to your secondary path, most Shyvana players prefer to go with Inspiration. Inspiration opens creative opportunities on Shyvana troughout the match. On the Inspiration path, the best runes for Shyvana are 
Cosmic Insight and 
Magical Footwear.
Cosmic Insight grants summoner spell and item haste. Magical Footwear allows Shyvana to focus on those essential core items without the need to spend the additional 300 gold on boots.
FAQ for Shyvana Runes
Which is the best keystone rune on Shyvana?
The best keystone rune on Shyvana is Dark Harvest. This Shyvana runes setup is then referred as Shyvana Dark Harvest.
What runes does Shyvana use?
Runes from the paths Domination and Inspiration are the most used runes on Shyvana. For the exact pick rates of Shyvana runes used, you have to study the rune distribution presented.