Kalista Runes explained
There's one set of runes for Kalista on patch 14.10 that is the clear favorite for LoL players and pros alike. The best Kalista rune paths on the position 
Adc are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 34%. Besides picking runes on Kalista you should learn how to play Kalista and if you are interested in pro matches take a look on how a pro builds Kalista. If you want to discuss 
Kalista then you should visit the champion subreddit.
Kalista runes from primary path
Domination improves burst damage and assassination tools on Kalista. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Hail of Blades is the best keystone rune to run on Kalista. This keystone rune helps you to win short damage trades in your lane by increasing your attackspeed at the beginning of a fight. Other primary runes on Kalista are 
Sudden Impact, 
Eyeball Collection and 
Treasure Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Kalista with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives Kalista additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Kalista will gain an additional 70 gold for the first takedown. Kalista acquires Bounty Hunter Stacks, which Kalista may use to get more takedowns. This rune's power will grow tremendously, and Kalista will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Kalista will get an additional twenty gold.
Kalista runes from secondary path
When it comes to your secondary path, most Kalista players prefer to go with Inspiration. Inspiration opens creative opportunities on Kalista troughout the match. On the Inspiration path, the best runes for Kalista are 
Biscuit Delivery and 
Cosmic Insight.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
FAQ for Kalista Runes
Which is the best keystone rune on Kalista?
The best keystone rune on Kalista is Hail of Blades. This Kalista runes setup is then referred as Kalista Hail of Blades.
What runes does Kalista use?
Runes from the paths Domination and Inspiration are the most used runes on Kalista. For the exact pick rates of Kalista runes used, you have to study the rune distribution presented.