Akali Runes explained
There's one set of runes for Akali on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Akali rune paths on the position 
Mid are 
Precision as the primary path and 
Resolve as the secondary path with a pick rate of 90%. Besides picking runes on Akali you should learn how to play Akali and if you are interested in pro matches take a look on how a pro builds Akali. If you want to discuss 
Akali then you should visit the champion subreddit.
Akali runes from primary path
Precision improves attack and sustained damage on Akali troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Fleet Footwork is the best keystone rune to run on Akali. This keystone rune generates you a lot of sustain and increases your survivability against poke champions in lane. Other primary runes on Akali are 
Presence of Mind, 
Legend: Tenacity and 
Last Stand.
Presence of Mind helps Akali with the mana problems by restoring missing mana, if a champion is killed. Akali gains extra Tenacity with every additional stage of Legend: Tenacity. With Last Stand you deal more damage while you are at low health.
Akali runes from secondary path
When it comes to your secondary path, most Akali players prefer to go with Resolve. Resolve empowers the survivability of Akali and increases the tankiness. On the Resolve path, the best runes for Akali are 
Second Wind and 
Overgrowth.
Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion. Overgrowth increases your maximum amount of health.
FAQ for Akali Runes
Which is the best keystone rune on Akali?
The best keystone rune on Akali is Fleet Footwork. This Akali runes setup is then referred as Akali Fleet Footwork.
What runes does Akali use?
Runes from the paths Precision and Resolve are the most used runes on Akali. For the exact pick rates of Akali runes used, you have to study the rune distribution presented.