Vayne Runes explained
There's one set of runes for Vayne on patch 14.9 that is the clear favorite for LoL players and pros alike. The best Vayne rune paths on the position 
Top are 
Precision as the primary path and 
Sorcery as the secondary path with a pick rate of 78%. Besides picking runes on Vayne you should learn how to play Vayne and if you are interested in pro matches take a look on how a pro builds Vayne. If you want to discuss 
Vayne then you should visit the champion subreddit.
Vayne runes from primary path
Precision improves attack and sustained damage on Vayne troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Fleet Footwork is the best keystone rune to run on Vayne. This keystone rune generates you a lot of sustain and increases your survivability against poke champions in lane. Other primary runes on Vayne are 
Presence of Mind, 
Legend: Alacrity and 
Cut Down.
Presence of Mind helps Vayne with the mana problems by restoring missing mana, if a champion is killed. Legend: Alacrity grants additional attack speed to Vayne. If the enemy team consists of multiple tanks, then the rune Cut Down is the best choice.
Vayne runes from secondary path
When it comes to your secondary path, most Vayne players prefer to go with Sorcery. Sorcery empoweres abilities of Vayne and increases the available champion resources. On the Sorcery path, the best runes for Vayne are 
Nimbus Cloak and 
Celerity.
Nimbus Cloak, which grants movement speed upon using a summoner spell, works amazingly well with junglers in particular as they take the shortest cooldown summoner spell, 
Smite. Celerity boosts all movement speed bonuses to Vayne.
FAQ for Vayne Runes
Which is the best keystone rune on Vayne?
The best keystone rune on Vayne is Fleet Footwork. This Vayne runes setup is then referred as Vayne Fleet Footwork.
What runes does Vayne use?
Runes from the paths Precision and Sorcery are the most used runes on Vayne. For the exact pick rates of Vayne runes used, you have to study the rune distribution presented.