Naafiri Runes explained
There's one set of runes for Naafiri on patch 14.9 that is the clear favorite for LoL players and pros alike. The best Naafiri rune paths on the position 
Mid are 
Inspiration as the primary path and 
Domination as the secondary path with a pick rate of 71%. Besides picking runes on Naafiri you should learn how to play Naafiri and if you are interested in pro matches take a look on how a pro builds Naafiri.
Naafiri runes from primary path
Inspiration opens creative opportunities on Naafiri troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
First Strike is the best keystone rune to run on 
Naafiri. Other primary runes on Naafiri are 
Magical Footwear, 
Biscuit Delivery and 
Cosmic Insight.
Magical Footwear allows Naafiri to focus on those essential core items without the need to spend the additional 300 gold on boots. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
Naafiri runes from secondary path
When it comes to your secondary path, most Naafiri players prefer to go with Domination. Domination improves burst damage and assassination tools on Naafiri. On the Domination path, the best runes for Naafiri are Treasure Hunter and Sudden Impact.
Treasure Hunter is the final rune of the Domination path. This rune gives Naafiri additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Naafiri will gain an additional 70 gold for the first takedown. Naafiri acquires Bounty Hunter Stacks, which Naafiri may use to get more takedowns. This rune's power will grow tremendously, and Naafiri will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Naafiri will get an additional twenty gold. Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Naafiri with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier.
FAQ for Naafiri Runes
Which is the best keystone rune on Naafiri?
The best keystone rune on Naafiri is First Strike. This Naafiri runes setup is then referred as Naafiri First Strike.
What runes does Naafiri use?
Runes from the paths Inspiration and Domination are the most used runes on Naafiri. For the exact pick rates of Naafiri runes used, you have to study the rune distribution presented.